1448851-91-9

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 675124-80-8 methyl [(2S,3R)-2,3-diamino-3-phenyl]propanoate 
• 150884-50-7 benzaldehyde N-boc imine 
• 1373550-33-4 methyl (2S,3R)-2-amino-3-((tert-butoxycarbonyl)amino)-3-phenylpropanoate 
• 1219152-49-4 methyl (2S,3R)-3-(tert-butoxycarbonylamino)-2-(diphenylmethyleneamino)-3-phenylpropanoate 

Relevant academic research and scientific papers

Cyclopropenimine-catalyzed enantioselective mannich reactions of tert -butyl glycinates with N -Boc-imines

Cyclopropenimine 1 is shown to catalyze Mannich reactions between glycine imines and N-Boc-aldimines with high levels of enantio- and diastereocontrol. The reactivity of 1 is shown to be substantially greater than that of a widely used thiourea cinchona alkaloid-derived catalyst. A variety of aryl and aliphatic N-Boc-aldimines are effective substrates for this transformation. A preparative-scale reaction to deliver >90 mmol of product is shown using 1 mol % catalyst. The products of this transformation can be converted into several useful derivatives.