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Upstream product

• 913960-96-0 C₂₂H₂₈N₈O₅ 
• 913960-95-9 1-Methyl-4-[(4-nitro-1H-pyrrole-2-carbonyl)-amino]-1H-pyrrole-2-carboxylic acid (3-dimethylamino-propyl)-amide 
• 78486-14-3 3-(1-methyl-4-aminopyrrole-2-carbonylamino)propyldimethylamine 
• 65361-30-0 N-[3-(dimethylamino)propyl]-1-methyl-4-nitro-1H-pyrrole-2-carboxamide 
• 115592-72-8 2-Bromthioessigsaeure-S-(p-tolyl)ester 
• 913960-97-1 N-[3-(dimethylamino)propyl]-1-methyl-4-[(4-{[1-methyl-4-(methylcarboxamido)-1H-2-pyrrolyl]carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide 

Relevant academic research and scientific papers

Toward encoding reactivity using double-stranded DNA. Sequence-dependent native chemical ligation of DNA binding polyamides

The coupling reaction between distamycin-related polyamides equipped with cysteine and thioester groups can be accelerated in the presence of double-stranded (ds) oligonucleotides with selected sequences. While the coupling reaction of reactive partners containing three pyrrole units is accelerated by dsDNAs containing ATTTTA or ATGTTA sites, the heterodimeric coupling between a tripyrrole and a polyamide equipped with two pyrroles and one imidazole, is accelerated by the latter DNA, but not by the other containing the A/T rich tract. These differences can be exploited for selecting preferred coupling pairs from a mixture of reactive monomers; therefore the reaction outcome depends on the instructions provided by the dsDNA sequence.