1448870-40-3

Upstream product

• 72130-98-4 (Z)-1-(dimethylamino)-3-methoxy-N-methylidyne-3-oxoprop-1-en-2-aminium 
• 1150618-50-0 1-isopropyl-1H-imidazole-4-carboxylic acid methyl ester 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 1620583-21-2 2-bromo-1-isopropyl-1H-imidazole-4-carboxylic acid methyl ester 
• 40137-29-9 2-methyl-4-chlorobenzaldehyde 
• 1620583-20-1 1-isopropyl-2-(2-methoxy-phenyl)-1H-imidazole-4-carboxylic acid methyl ester 
• 1620583-18-7 methyl 5-((4-chloro-2-methylphenyl)(methylsulfonyloxy)methyl)-1-isopropyl-2-(2-methoxyphenyl)-1H-imidazole-4-carboxylate 
• 2106-04-9 3-chloro-2-fluoroaniline 

Downstream Products

• 1448867-02-4 5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-2-(2-methoxy-phenyl)-5,6-dihydro-1H-pyrrolo[3,4-d]imidazole-4-one 
• 1448870-39-0 5-(3-chloro-2-fluoro-phenylamino)-(4-chloro-2-methyl-phenyl)-1-isopropyl-2-(2-methoxy-phenyl)-1H-imidazole-4-carboxylic acid 
• 1620582-86-6 1-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-2-methyl-phenyl)-7-isopropyl-8-(2-methoxy-phenyl)-1,3,6,7-tetrahydro-purin-2-one 
• 1620583-17-6 lithium 5-[(3-chloro-2-fluoro-phenylamino)-(4-chloro-2-methyl-phenyl)methyl]-1-isopropyl-2-(2-methoxy-phenyl)-1H-imidazole-4-carboxylate 

Relevant academic research and scientific papers

SUBSTITUTED PURINONE COMPOUNDS

The invention relates to compounds of formula (I): (I) as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.

IMIDAZOPYRROLIDINONE COMPOUNDS

The invention relates to compounds of formula (I): (I) as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.