1448902-07-5

Upstream product

• 1263198-04-4 methyl (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-1-(2-nitrophenyl)sulfonylpiperidine-3-carboxylate 
• 1263198-15-7 methyl (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxylate 
• 1263198-12-4 1-tert-butyl 3-methyl (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-1,3-dicarboxylate 
• 1263198-18-0 (3S,5R)-1-tert-butoxycarbonyl-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxylic acid 
• 1263198-01-1 methyl (3S,5R)-5-{[2-(2-chloroanilino)-1,1-dimethylethyl]amino}-1-(2-nitrophenyl)sulfonylpiperidine-3-carboxylate 
• 1263197-96-1 methyl (3S,5R)-5-[(1,1-dimethyl-2-oxoethyl)amino]-1-(2-nitrophenyl)sulfonylpiperidine-3-carboxylate 
• 1448902-05-3 1-tert-Butyl 3-methyl (3S,5R)-5-[(1,1-dimethyl-2-oxoethyl)amino]piperidine-1,3-dicarboxylate 
• 1263197-89-2 1-tert-butyl 3-methyl (3S,5R)-5-aminopiperidine-1,3-dicarboxylate 
• 82465-52-9 3-methyl-1-(3-pyridyl)butan-1-one 
• 1448902-43-9 (S_S)-2-methyl-N-[(1R)-3-methyl-1-(3-pyridyl)butyl]propane-2-sulfinamide 
• 1448902-04-2 1-tert-butyl 3-methyl (3S,5R)-5-(benzyloxycarbonylamino)piperidine-1,3-dicarboxylate 
• 534572-20-8 (3S,5R)-1-(tert-butoxycarbonyl)-3-(methoxycarbonyl)piperidine-5-carboxylic acid 

Downstream Products

• 1263197-27-8 C₂₈H₃₈ClN₅O₂ 

Relevant academic research and scientific papers

Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4- phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors

We report synthesis and optimization of a series of (3S,5R)-5-(2,2- dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as renin inhibitors. Chemical modification of P1, P2 and P 3 portions led to a promising 3