1448902-63-3

Upstream product

• 534572-20-8 (3S,5R)-1-(tert-butoxycarbonyl)-3-(methoxycarbonyl)piperidine-5-carboxylic acid 
• 1415413-38-5 C₁₆H₂₆N₂O₆ 
• 1263198-07-7 (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-1-(2-nitrophenyl)sulfonylpiperidine-3-carboxylic acid 
• 1448902-03-1 (4R)-4-amino-2,6-dimethylheptan-3-ol hydrochloride 
• 1448902-05-3 1-tert-Butyl 3-methyl (3S,5R)-5-[(1,1-dimethyl-2-oxoethyl)amino]piperidine-1,3-dicarboxylate 
• 1263197-89-2 1-tert-butyl 3-methyl (3S,5R)-5-aminopiperidine-1,3-dicarboxylate 
• 1448902-04-2 1-tert-butyl 3-methyl (3S,5R)-5-(benzyloxycarbonylamino)piperidine-1,3-dicarboxylate 
• 944141-72-4 C₉H₂₁NO 
• 1263198-04-4 methyl (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-1-(2-nitrophenyl)sulfonylpiperidine-3-carboxylate 
• 1263198-01-1 methyl (3S,5R)-5-{[2-(2-chloroanilino)-1,1-dimethylethyl]amino}-1-(2-nitrophenyl)sulfonylpiperidine-3-carboxylate 
• 1263197-96-1 methyl (3S,5R)-5-[(1,1-dimethyl-2-oxoethyl)amino]-1-(2-nitrophenyl)sulfonylpiperidine-3-carboxylate 
• 1263197-99-4 C₁₆H₂₁N₃O₇S 
• 1263197-94-9 C₁₉H₂₉N₃O₈S 
• 1415413-37-4 C₁₃H₁₇N₃O₆S 

Downstream Products

• 1448902-85-9 C₂₇H₄₃ClN₄O₃ 

Relevant academic research and scientific papers

Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4- phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors

We report synthesis and optimization of a series of (3S,5R)-5-(2,2- dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as renin inhibitors. Chemical modification of P1, P2 and P 3 portions led to a promising 3

Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5- oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors

Utilizing X-ray crystal structure analysis, (3S,5R)-5-[4-(2-chlorophenyl)- 2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides were designed and identified as renin inhibitors. The most potent compound 15 demonstrated favorable pharmacokinetic and