144895-66-9Relevant academic research and scientific papers
De novo asymmetric syntheses of C-4-substituted sugars via an iterative dihydroxylation strategy
Ahmed, Md. Moinuddin,O'Doherty, George A.
, p. 1505 - 1521 (2007/10/03)
A short and highly efficient route to various C-4 substituted sugar lactones has been developed. The key to the overall transformation is the sequential osmium-catalyzed dihydroxylation reaction of substituted 2,4-dienoates and an allylic substitution at
De novo enantioselective syntheses of galacto-sugars and deoxy sugars via the iterative dihydroxylation of dienoate
Ahmed, Moinuddin Md.,Berry, Bryan P.,Hunter, Thomas J.,Tomcik, Dennis J.,O'Doherty, George A.
, p. 745 - 748 (2007/10/03)
(Chemical Equation Presented) An efficient route to various sugar lactones has been developed. Key to the overall transformation is the sequential osmium-catalyzed dihydroxylation of 2,4-dienoates. The simplest (one-step/racemic) example of this reaction occurs when the dihydroxylation is performed with aqueous NMO in MeOH. When the first dihydroxylation is performed using the AD-mix procedure, an enantioselective variant results. When a matched AD-mix procedure is used for the second dihydroxylation, an exceedingly diastereo- and enantioselective synthesis of galacto-1,4-lactone results.
De novo synthesis of galacto-sugar δ-lactones via a catalytic osmium/palladium/osmium reaction sequence
Ahmed, Md. Moinuddin,O'Doherty, George A.
, p. 3015 - 3019 (2007/10/03)
A highly efficient route to various 1,5-galacto-sugar lactones from dienoates has been developed by using three catalytic reactions. These reactions include (i) an enantioselective osmium-catalyzed dihydroxylation, (ii) a regio- and diastereoselective pal
