144896-95-7Relevant academic research and scientific papers
Application of enantiopure templated azomethine ylids to β-hydroxy-α- amino acid synthesis
Alker, David,Hamblett, Giles,Harwood, Laurence M.,Robertson, Sarah M.,Watkin, David J.,Williams, C. Eleri
, p. 6089 - 6098 (1998)
Chiral stabilised azomethine ylids derived from the reaction of (5S)-5- phenylmorpholin-2-one (1) with aldehydes undergo efficient and highly diastereocontrolled cycloaddition with a second molecule of aldehyde to furnish products (2) which may be converted into enantiomerically pure threo (2S,3R) β-hydroxy-α-amino acids (3) in excellent yield.
Asymmetric Cycloadditions of Aldehydes to Stabilised Azomethine Ylids: Enantiocontrolled Construction of β-Hydroxy-α-amino acid Derivatives
Harwood, Laurence M.,Macro, Jason,Watkin, David,Williams, C. Eleri,Wong, Ling F.
, p. 1127 - 1130 (2007/10/02)
In the absence of added dipolarophile, chiral stabilised azomethine ylids derived from the reaction of 5-(S)-phenylmorpholin-2-one (1) with aldehydes undergo efficient and highly enantiocontrolled cycloaddition with a second molecule of aldehyde to furnis
