1448962-63-7

Basic information

• Product Name: 4-([1,4'-bipiperidin]-1'-ylmethyl)-2-phenylbenzofuran-5-yl trifluoromethanesulfonate
• Synonyms: 4-([1,4'-bipiperidin]-1'-ylmethyl)-2-phenylbenzofuran-5-yl trifluoromethanesulfonate
• CAS NO: 1448962-63-7
• Molecular Weight: 522.588
• Mol File: 1448962-63-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-([1,4'-bipiperidin]-1'-ylmethyl)-2-phenylbenzofuran-5-yl trifluoromethanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-([1,4'-bipiperidin]-1'-ylmethyl)-2-phenylbenzofuran-5-yl trifluoromethanesulfonate(1448962-63-7)
• EPA Substance Registry System: 4-([1,4'-bipiperidin]-1'-ylmethyl)-2-phenylbenzofuran-5-yl trifluoromethanesulfonate(1448962-63-7)

Safety Data

• Hazardous Substances Data: 1448962-63-7(Hazardous Substances Data)

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 1448962-45-5 4-((1,4'-bipiperidin)-1'-ylmethyl)-2-phenylbenzofuran-5-ol 
• 4897-50-1 4-piperidinopiperidin 
• 7182-29-8 5-hydroxy-2-phenylbenzofuran 

Relevant articles and documents

Benzofuran derivatives as anticancer inhibitors of mTOR signaling

A series of 32 derivatives and isosteres of the mTOR inhibitor 2 were synthesized and compared for their cytotoxicity in radioresistant SQ20B cancer cell line. Several of these compounds, in particular 30b, were significantly more cytotoxic than 2. Importantly, 30b was shown to block both mTORC1 and Akt signaling, suggesting insensitivity to the resistance associated to Akt overactivation observed with rapamycin derivatives currently used in clinic.