1448989-42-1

Basic information

• Product Name: (R)-methyl 5-(benzylthio)-3-(4-chlorophenyl)-5-oxopentanoate
• CAS NO: 1448989-42-1
• Molecular Weight: 362.877
• Mol File: 1448989-42-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-methyl 5-(benzylthio)-3-(4-chlorophenyl)-5-oxopentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-methyl 5-(benzylthio)-3-(4-chlorophenyl)-5-oxopentanoate(1448989-42-1)
• EPA Substance Registry System: (R)-methyl 5-(benzylthio)-3-(4-chlorophenyl)-5-oxopentanoate(1448989-42-1)

Safety Data

• Hazardous Substances Data: 1448989-42-1(Hazardous Substances Data)

Upstream product

• 18107-18-1 diazomethyl-trimethyl-silane 

Relevant articles and documents

Highly enantioselective thiolysis of prochiral cyclic anhydrides catalyzed by amino alcohol bifunctional organocatalysts and its application to the synthesis of pregabalin

Asymmetric thiolysis of prochiral cyclic anhydrides was achieved with our developed chiral sulfonamide and squaramide bifunctional organocatalysts based on amino alcohol scaffolds. The corresponding thioesters were obtained in high yields with excellent enantioselectivities. The usefulness of this methodology was demonstrated in the enantioselective synthesis of pregabalin. A highly enantioselective thiolysis of prochiral cyclic anhydrides was achieved with chiral sulfonamide bifunctional organocatalysts based on an amino alcohol scaffold. The usefulness of this methodology was demonstrated through a synthetic application to pregabalin. Copyright