1448993-47-2Relevant academic research and scientific papers
α-Regioselective construction of gem-bisprenyl structures via zinc-mediated prenylation of esters in THF
Zhao, Li-Ming,Wan, Li-Jing,Zhang, Shu-Qing,Sun, Rui,Ma, Feng-Yan
, p. 7970 - 7974 (2013)
The in situ generated prenylzinc reagent from the reaction of zinc with prenyl bromide has been shown to undergo a new type of α-regioselective addition reaction with a wide range of esters that affords gem-bisprenyl structures. The reaction proceeds under mild conditions to provide α,α′-adducts with complete α-regioselectivity. A mechanism with the consideration of the steric factors is proposed to account for the regioselective results.
