1449-60-1

Basic information

• Product Name: 5α-Ergosta-7,22-dien-3β-ol acetate
• Synonyms: 5α-Ergosta-7,22-dien-3β-ol acetate
• CAS NO: 1449-60-1
• Molecular Formula: C₃₀H₄₈O₂
• Molecular Weight: 440.70092
• Mol File: 1449-60-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5α-Ergosta-7,22-dien-3β-ol acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 5α-Ergosta-7,22-dien-3β-ol acetate(1449-60-1)
• EPA Substance Registry System: 5α-Ergosta-7,22-dien-3β-ol acetate(1449-60-1)

Safety Data

• Hazardous Substances Data: 1449-60-1(Hazardous Substances Data)

Upstream product

• 5035-32-5 3-epi-5,6-dihydroergosterol 
• 28421-56-9 3β-acetoxy-5α,8α-(4-phenyl-1,2,4-triazolidine-3,5-dione-1,2-diyl)ergosta-6,22-diene 
• 57-87-4 ergosterol 
• 1105-11-9 (3S,5S,9R,10S,13R,17R)-10,13-Dimethyl-17-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol 
• 57-87-4 Ergosterol 
• 2465-11-4 (22E)-ergosta-7,22-dien-3β-ol 
• 75-36-5 acetyl chloride 
• 142186-92-3 ergosta-7,22-dien-3β-yl palmitate 
• 108-24-7 acetic anhydride 
• 1108-03-8 ergosterol acetate 
• 27245-94-9 24β_F-methyl-5β-cholestadien-(7.22t-ol-(3α) 
• 1431-87-4 ergosta-7,22-diene-3-one 
• 128-27-8 (10S)-3t-Hydroxy-10r.13t-dimethyl-17t-((1R:4R)-1.4.5-trimethyl-hexen-(2t)-yl)-(9cH.14cH)-Δ^5.7-dodecahydro-1H-cyclopenta[a]phenanthren 
• 1105-11-9 5α.10α-ergostadien-(7.22t)-ol-(3β) 

Downstream Products

• 4042-95-9 3β-acetoxy-5α-ergost-8(14)-ene 
• 474-59-9 5β-lumistanol-(3α) 
• 116282-74-7 3.5-dinitro-benzoic acid-(5α.10α-ergostanyl-(3α)-ester) 
• 474-59-9 24β_F-methyl-5α.10α-cholestanol-(3α) 
• 632-32-6 (3β,5α)-ergost-8(14)-en-3-ol 
• 55401-50-8 (3S,5S,8R,9S,10S,13R,17R)-17-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate 
• 4356-15-4 3β-acetoxy-5α-ergosta-8(14),22t-diene 
• 53866-87-8 (3S,5S,7S,8S,9R,10S,13R,14R,17R)-10,13-Dimethyl-17-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-hexadecahydro-cyclopropa[7,8]cyclopenta[a]phenanthren-3-ol 
• 15071-36-0 (R)-2,3-dimethylbutan-1-ol 
• 4356-09-6 campestanyl acetate 
• 4356-09-6 acetic acid-(5α-ergostan-3α-yl ester) 
• 474-59-9 (10S)-3c-Hydroxy-10r.13c-dimethyl-17c-((1R:4S)-1.4.5-trimethyl-hexyl)-(5ξH.8ξH.9cH.14tH)-hexadecahydro-1H-cyclopenta[a]phenanthren 
• 516-78-9 (3β,5α)-ergost-7-en-3-ol 
• 14646-73-2 3β-acetoxy-5α-pregn-7-en-20-one 

Relevant articles and documents

THREE TRITERPENES FROM ASTRAEUS HYGROMETRICUS

Three new triterpenes, as well as two known steroids, were isolated from Astraeus hygrometricus.The structures of the new triterpenes were established by chemical and spectroscopic means.Key Word Index - Astraeus hygrometricus; Basidiomyces; higher fungi; triterpenoids; Astrahygrol; 3-epi-astrahygrol; astrahygrone.

Ergosterol analogs as inhibitors of cyclin dependent kinase 8

Five new compounds based on the structure of ergosterol have been prepared and tested for their ability to inhibit CDK8. The design of the compounds was inspired by the previous reported CDK8 inhibitors, cortistatin A, CCT251921 and Senexin A. The two most potent compounds, 16a and 16d, inhibited the target enzyme with Kd-values of 107 and 93 nM, respectively.

SYNTHESIS OF POTENTIAL ECDYSTEROID PRECURSORS FROM Δ7,22 STEROLS

Two routes for the conversion of 5α-cholest-7-ene-3β-ol (11) into 7, which has the typical ecdysteroid substitution pattern in rings B, C, and D, have been developed.Making use of one of the methods, 5,6-dihydroergosterol (31) was converted into the 38, p