144900-57-2

Usage

Uses

Used in Pharmaceutical Synthesis:
(2-Chloropyridin-4-yl)methanamine is used as a building block for the development of pharmaceuticals, leveraging its chemical reactivity to form new compounds with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, (2-Chloropyridin-4-yl)methanamine serves as an intermediate in the synthesis of various agrochemicals, contributing to the creation of products designed to protect crops and enhance agricultural yields.
Used in Fine Chemicals Synthesis:
(2-Chloropyridin-4-yl)methanamine is also utilized in the synthesis of fine chemicals, where its unique structure and reactivity are employed to produce specialty chemicals for various applications.
Used in Organic Compounds Production:
(2-Chloropyridin-4-yl)methanamine is used as an intermediate in the production of organic compounds such as dyes and pigments, where its pyridine-based structure imparts specific color and properties.
Used in Corrosion Inhibitors:
It finds application in the development of corrosion inhibitors, where its chemical composition helps in preventing or reducing the corrosion of metals in various industrial settings.
Used in Medicinal Chemistry and Drug Discovery Research:
Due to its structural features, (2-Chloropyridin-4-yl)methanamine may have potential applications in medicinal chemistry and drug discovery research, where it could be explored for its capacity to interact with biological targets and contribute to the development of new medications.
It is important to handle (2-Chloropyridin-4-yl)methanamine with care due to its potential health and environmental risks, ensuring safe practices in its synthesis and application.

InChI:InChI=1/C6H7ClN2/c7-6-3-5(4-8)1-2-9-6/h1-3H,4,8H2

Upstream product

• 33252-30-1 2-chloro-4-pyridinenitrile 

Downstream Products

• 916210-27-0 tert-butyl N-[(2-chloro-4-pyridyl) methyl]carbamate 

Relevant academic research and scientific papers

Pyridine methylamine compound and preparation method thereof

The invention provides a pyridine methylamine compound and a preparation method thereof. The preparation method comprises the steps that tetrahydrofuran and sodium borohydride are sequentially added into a cyanopyridine compound, then an iodine-containing tetrahydrofuran solution is dropwise added, a reaction is conducted at the temperature of 20-30 DEG C, and after dropwise adding is completed, stirring is carried out continuously; after the reaction is finished, methanol is added for refluxing, extracting and spin-drying are carried out to obtain the pyridine methylamine compound; wherein a functional group in the cyanopyridine compound is selected from chlorine, bromine, methyl, ethyl, amino or hydrogen; according to the preparation method, high-temperature and high-pressure special equipment does not need to be used, so that the preparation method is relatively safe, and dangerous accidents such as explosion and fire disasters are avoided; besides, the preparation method is relatively environment-friendly, recycling treatment of hazardous waste (used Raney nickel) is not involved, the economic benefit is relatively high, borane generated by the synthesis method is converted into boric acid esters in the post-treatment process, the treatment cost is low, and the harm to the environment is much small.

Hydrogenation of Nitriles and Ketones Catalyzed by an Air-Stable Bisphosphine Mn(I) Complex

Efficient hydrogenations of nitriles and ketones with molecular hydrogen catalyzed by a well-defined bench-stable bisphosphine Mn(I) complex are described. These reactions are environmentally benign and atomically economic, implementing an inexpensive, earth-abundant nonprecious metal catalyst. A range of aromatic and aliphatic nitriles and ketones were efficiently converted into primary amines and alcohols, respectively, in good to excellent yields. The hydrogenation of nitriles proceeds at 100 °C with catalyst loading of 2 mol % and 20 mol % base (t-BuOK), while the hydrogenation of ketones takes place already at 50 °C, with a catalyst loading of 1 mol % and 5 mol % of base. In both cases, a hydrogen pressure of 50 bar was applied.

Novel tricyclic inhibitors of IKK2: Discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6- dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066)

The synthesis, structure-activity relationships (SAR), and biological results of pyridyl-substituted azaindole based tricyclic inhibitors of IKK2 are described. Compound 4m demonstrated potent in vitro potency, acceptable pharmacokinetic and physicochemical properties, and efficacy when dosed orally in a mouse model of inflammatory bowel disease.

Quinazoline derivatives possessing anti-tumor activity

The invention relates to quinazoline derivatives, or pharmaceutically-acceptable salts thereof, which possess anti-tumor activity; to processes for their manufacture; and to pharmaceutical compositions containing them. The invention provides a quinazoline of the formula: STR1 wherein R1 is hydrogen or amino, or alkyl or alkoxy each of up to 6 carbon atoms; or R1 is substituted alkyl or alkoxy each of up to 3 carbon atoms; R2 is hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl, halogenoalkyl or cyanoalkyl each of up to 6 carbon atoms; Ar is phenylene or heterocyclene; L is a group of the formula --CO.NH--, --NH.CO--, --CO.NR3 --, --NR3. CO--, --CH=CH--, --CH2 O--, --OCH2, --CH2 S--, --SCH2 --, --CO.CH2 --, --CH2.CO-- or --CO.O--, wherein R3 is alkyl of up to 6 carbon atoms; and Y is aryl or heteroaryl or a hydrogenated derivative thereof: or Y is a group of the formula --A--Y1 in which A is alkylene, cycloalkylene, alkenylene or alkynylene each of up to 6 carbon atoms and Y1 is aryl or heteroaryl or a hydrogenated derivative thereof; or a pharmaceutically-acceptable salt thereof.