1449005-23-5Relevant academic research and scientific papers
Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: Optimization of kinase selectivity and pharmacokinetics
Hornberger, Keith R.,Chen, Xin,Crew, Andrew P.,Kleinberg, Andrew,Ma, Lifu,Mulvihill, Mark J.,Wang, Jing,Wilde, Victoria L.,Albertella, Mark,Bittner, Mark,Cooke, Andrew,Kadhim, Salam,Kahler, Jennifer,Maresca, Paul,May, Earl,Meyn, Peter,Romashko, Darlene,Tokar, Brianna,Turton, Roy
, p. 4511 - 4516 (2013/08/23)
The kinase selectivity and pharmacokinetic optimization of a series of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1 is described. The intersection of insights from molecular modeling, computational prediction of metabolic sites, and in vitro metabolite i
