1449035-87-3

Upstream product

• 622-97-9 1-ethenyl-4-methylbenzene 
• 108-24-7 acetic anhydride 
• 73960-72-2 methyl-2,3-didehydro-4,7,8,9-tetra-O-acetyl-N-acetylneuraminate 

Downstream Products

• 1449035-90-8 methyl 5-acetamido-7,8,9-tri-O-acetyl-2,6-anhydro-3,5-dideoxy-3-C-[3'-(p-tolyl)prop-2'-enyl]-D-glycero-D-talo-non-2-enonate 
• 1449035-88-4 3-(p-tolyl)allyl-Neu₅Ac₂en 4,5-oxazoline 
• 1449035-89-5 methyl 5-acetamido-7,8,9-tri-O-acetyl-2,6-anhydro-4-azido-3,4,5-trideoxy-3-C-[3'-(p-tolyl)aziridin-2'-methyl]-D-glycero-D-galacto-non-2-enonate 
• 1449035-92-0 methyl 5-acetamido-7,8,9-tri-O-acetyl-2,6-anhydro-4-azido-3,4,5-trideoxy-3-C-[3'-(p-tolyl)prop-2'-enyl]-D-glycero-D-galacto-non-2-enonate 
• 1449035-81-7 5-acetamido-4-amino-2,6-anhydro-3,4,5-trideoxy-3-C-[3'-(p-tolyl)prop-2'-enyl]-D-glycero-D-galacto-non-2-enonic acid 
• 1449035-93-1 methyl 5-acetamido-2,6-anhydro-4-azido-3,4,5-trideoxy-3-C-[3'-(p-tolyl)prop-2'-enyl]-D-glycero-D-galacto-non-2-enonate 
• 1449035-94-2 methyl 5-acetamido-2,6-anhydro-4-amino-3,4,5-trideoxy-3-C-[3'-(p-tolyl)prop-2'-enyl]-D-glycero-D-galacto-non-2-enonate 
• 1449035-95-3 methyl 5-acetamido-2,6-anhydro-4-[2,3-bis(tert-butoxycarbonyl)guanidino]-3,4,5-trideoxy-3-C-[3'-(p-tolyl)prop-2'-enyl]-D-glycero-D-galacto-non-2-enonate 
• 1449035-82-8 5-acetamido-2,6-anhydro-3,4,5-trideoxy-4-guanidino-3-C-[3'-(p-tolyl)prop-2'-enyl]-D-glycero-D-galacto-non-2-enonic acid 
• 1449035-96-4 methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-2,6-anhydro-3,5-dideoxy-3-C-[3'-(p-tolyl)prop-2'-enyl]-D-glycero-D-talo-non-2-enonate 
• 1449035-97-5 methyl 5-acetamido-7,8,9-tri-O-acetyl-2,6-anhydro-4-azido-3,4,5-trideoxy-3-C-[3'-(p-tolyl)prop-2'-enyl]-D-glycero-D-talo-non-2-enonate 
• 1449035-98-6 methyl 5-acetamido-2,6-anhydro-4-azido-3,4,5-trideoxy-3-C-[3'-(p-tolyl)prop-2'-enyl]-D-glycero-D-talo-non-2-enonate 
• 1449035-99-7 methyl 5-acetamido-2,6-anhydro-4-amino-3,4,5-trideoxy-3-C-[3'-(p-tolyl)prop-2'-enyl]-D-glycero-D-talo-non-2-enonate 
• 1449035-83-9 5-acetamido-2,6-anhydro-4-amino-3,4,5-trideoxy-3-C-[3'-(p-tolyl)prop-2'-enyl]-D-glycero-D-talo-non-2-enonic acid 

Relevant academic research and scientific papers

Novel 3,4-disubstituted-Neu5Ac2en derivatives as probes to investigate flexibility of the influenza virus sialidase 150-loop

Novel 3,4-disubstituted-Neu5Ac2en derivatives have been synthesised to probe the open 150-loop conformation of influenza virus sialidases. Both equatorially and axially (epi) substituted C4 amino and guanidino 3-(p-tolyl)allyl-Neu5Ac2en derivatives were prepared, via the 4-epi-hydroxy derivative. The equatorially-substituted 4-amino derivative showed low micromolar inhibition of both group-1 (pdm09 H1N1) and group-2 (pdm57 H2N2) sialidases, and provides the first in vitro evidence that a group-2 sialidase may exhibit 150-loop flexibility.