1449136-90-6

Basic information

• Product Name: 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxylic acid ((R)-1-phenylpropyl)amide
• Synonyms: 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxylic acid ((R)-1-phenylpropyl)amide
• CAS NO: 1449136-90-6
• Molecular Weight: 284.358
• Mol File: 1449136-90-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxylic acid ((R)-1-phenylpropyl)amide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxylic acid ((R)-1-phenylpropyl)amide(1449136-90-6)
• EPA Substance Registry System: 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxylic acid ((R)-1-phenylpropyl)amide(1449136-90-6)

Safety Data

• Hazardous Substances Data: 1449136-90-6(Hazardous Substances Data)

Upstream product

• 1449136-32-6 4-formylmorpholine-3-carboxylic acid 
• 1449136-33-7 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxylic acid ethyl ester 
• 1449136-89-3 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxylic acid 
• 2941-20-0 1-phenylpropylamine 

Downstream Products

• 1449137-70-5 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-{[(R)-1-(6-methoxypyridin-3-yl)propyl]amide} 8-[((R)-1-phenylpropyl)amide] 
• 1449137-71-6 {[8-((R)-1-phenylpropylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbonyl]amino}acetic acid ethyl ester 
• 1449137-73-8 (R)-1-[8-((R)-1-phenylpropylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbonyl]pyrrolidine-2-carboxylic acid methyl ester 
• 1449137-74-9 (R)-1-[8-((R)-1-phenylpropylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbonyl]pyrrolidine-2-carboxylic acid isopropyl ester 
• 1449137-78-3 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-[(3,5-dimethylisoxazol-4-ylmethyl)amide] 8-[((R)-1-phenylpropyl)amide] 
• 1449137-02-3 6-bromo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxylic acid ((R)-1-phenylpropyl)amide 
• 1449136-94-0 8-((R)-1-phenylpropylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carboxylic acid 
• 1449137-75-0 (R)-1-[8-((R)-1-phenylpropylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbonyl]pyrrolidine-2-carboxylic acid 
• 1449136-92-8 6-(2,2,2-trichloroacetyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxylic acid ((R)-1-phenylpropyl)amide 

Relevant articles and documents

FUSED PYRROLEDICARBOXAMIDES AND THEIR USE AS PHARMACEUTICALS

The present invention relates to fused pyrroledicarboxamides of the formula (I), in which R1 to R9, X, m and n are as defined in the claims. The compounds of the formula (I) are inhibitors of the acid-sensitive potassium channel TASK-1 and suitable for the treatment of TASK-1 channel-mediated diseases such as arrhythmias, in particular atrial arrhythmias like atrial fibrillation or atrial flutter, and respiratory disorders, in particular sleep-related respiratory disorders like sleep apnea, for example.