1449228-40-3

Basic information

• Product Name: Senexin B
• Synonyms: 4-(2-(6-(4-methylpiperazine-1-carbonyl)naphthalen-2-yl)ethylamino)quinazoline-6-carbonitrile;Senexin B
• CAS NO: 1449228-40-3
• Molecular Formula: C₂₇H₂₆N₆O
• Molecular Weight: 450.53
• Mol File: 1449228-40-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 724.8±60.0 °C(Predicted)
• Appearance: /
• Density: 1.32±0.1 g/cm3(Predicted)
• PKA: 6.74±0.10(Predicted)
• CAS DataBase Reference: Senexin B(CAS DataBase Reference)
• NIST Chemistry Reference: Senexin B(1449228-40-3)
• EPA Substance Registry System: Senexin B(1449228-40-3)

Safety Data

• Hazardous Substances Data: 1449228-40-3(Hazardous Substances Data)

Upstream product

• 77317-55-6 methyl 2-amino-5-iodobenzoate 
• 98556-31-1 4-chloro-6-iodoquinazoline 

Relevant articles and documents

INHIBITORS OF CDK8/19 FOR USE IN TREATING ESTROGEN RECEPTOR POSITIVE BREAST CANCER

The invention provides a selective inhibitor of CDK8/19 for use in a method of treating a patient having estrogen receptor positive (ER+) breast cancer, including breast cancer that is resistant to antiestrogen therapy. In some embodiments, the selective inhibitor of CDK8/19 is administered in combination with antiestrogen therapy. In some embodiments, the selective inhibitor of CDK8/19 is administered to ER + HER2+ breast cancer patients in combination with HER2-targeting drugs.