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Benzenemethanol, a-(azidomethyl)-4-methyl- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 144924-03-8 Structure
  • Basic information

    1. Product Name: Benzenemethanol, a-(azidomethyl)-4-methyl-
    2. Synonyms:
    3. CAS NO:144924-03-8
    4. Molecular Formula: C9H11N3O
    5. Molecular Weight: 177.206
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 144924-03-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Benzenemethanol, a-(azidomethyl)-4-methyl-(CAS DataBase Reference)
    10. NIST Chemistry Reference: Benzenemethanol, a-(azidomethyl)-4-methyl-(144924-03-8)
    11. EPA Substance Registry System: Benzenemethanol, a-(azidomethyl)-4-methyl-(144924-03-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 144924-03-8(Hazardous Substances Data)

144924-03-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 144924-03-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,9,2 and 4 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 144924-03:
(8*1)+(7*4)+(6*4)+(5*9)+(4*2)+(3*4)+(2*0)+(1*3)=128
128 % 10 = 8
So 144924-03-8 is a valid CAS Registry Number.

144924-03-8Relevant articles and documents

Functionalized 3 H -1,2,3,4-triazaphosphole derivatives: Synthesis and structural characterization of novel low-coordinate phosphorus heterocycles

Sklorz, Julian A. W.,Schnucklake, Maike,Kirste, Matthias,Weber, Manuela,Wiecko, Jelena,Müller, Christian

, p. 558 - 562 (2016)

The synthesis of novel functionalized 3H-1,2,3,4-triazaphosphole derivatives is presented, making use of the modular [3+2] dipolar cycloaddition reaction between an azide and a phosphaalkyne. These low-coordinate phosphorus heterocycles were prepared in high yield and could be characterized crystallographically. This strategy provides the possibility to access hitherto unknown chelating and potentially chiral P^O ligands based on triazaphospholes.

Concurrent Formation of N-H Imines and Carbonyl Compounds by Ruthenium-Catalyzed C-C Bond Cleavage of β-Hydroxy Azides

Lee, Jeong Min,Bae, Dae Young,Park, Jin Yong,Jo, Hwi Yul,Lee, Eunsung,Rhee, Young Ho,Park, Jaiwook

supporting information, p. 4608 - 4613 (2020/06/05)

A commercial cyclopentadienylrutenium dicarbonyl dimer ([CpRu(CO)2]2) efficiently catalyzes the formation of N-H imines and carbonyl compounds simultaneously from β-hydroxy azides via C-C bond cleavage under visible light. Density functional theory calculations for the cleavage reaction support the mechanism involving chelation of alkoxy azide species and liberation of nitrogen as the driving force. The synthetic utility of the reaction was demonstrated by a new amine synthesis promoted by chemoselective allylation of imine and synthesis of isoquinoline.

Halohydrin and its derivatives low priced high-efficient synthetic method (by machine translation)

-

Paragraph 0164; 0165; 0166; 0167, (2017/08/25)

The invention discloses a halohydrin low priced high-efficient synthetic method, the organic solvent of formula I shown in the olefin compound with a halide, sulfoxide and additive mixing, by the olefin of hydroxy halogenate reaction, can be a high selectivity of the halohydrin the system results in the type II shown, wherein R1 , R2 , R3 , R4 , R5 And R6 Are selected from hydrogen, halogen, alkyl, hydroxyalkyl, alkoxy, ester, acyl, amido, dialkyl amino, aryl, substituted aromatic, heterocyclic aromatic group or substituted heterocyclic aromatic, R1 , R2 , R3 , R4 , R5 And R6 The presence of the respective independent may be identical or different; or R1 And R2 , R1 And R3 , R2 And R4 , R3 And R4 , R5 And R6 Combining to form a cycloalkyl or substituted cycloalkyl, benzo ring alkyl or substituted cycloalkyl, heterocycle or substituted heterocycle; M selected from hydrogen, lithium, sodium, potassium, cesium, beryllium, magnesium, calcium, strontium, barium, zinc, copper, iron, ammonium or tetraalkyl ammonium; X chlorine, bromine or iodine. (by machine translation)

Visible-Light-Promoted Metal-Free Aerobic Hydroxyazidation of Alkenes

Yang, Bo,Lu, Zhan

, p. 8362 - 8365 (2017/12/08)

A highly efficient visible-light-promoted metal-free aerobic hydroxyazidation of alkenes has been developed. This protocol was operationally simple with broad substrate scope using relatively simple and readily available starting materials, such as alkene

Catalytic transformation of esters of 1,2-azido alcohols into α-amido ketones

Kim, Yongjin,Pak, Han Kyu,Rhee, Young Ho,Park, Jaiwook

supporting information, p. 6549 - 6552 (2016/06/01)

The esters of 1,2-azido alcohols were transformed into α-amido ketones without external oxidants through the Ru-catalyzed formation of N-H imines with the liberation of N2 followed by intramolecular migration of the acyl moiety. A wide range of α-amido ketones were obtained, and one-pot transformation into the corresponding oxazoles (or a thiazole) was demonstrated.

Oxidant controlled regio- and stereodivergent azidohydroxylation of alkenes via I2 catalysis

Prasad,Reddi,Sudalai

supporting information, p. 10276 - 10279 (2015/06/25)

A novel, I2 catalyzed regio- and stereodivergent vicinal azidohydroxylation of alkenes leading to 1,2-azidoalcohols in high yields (up to 92%) and excellent dr (up to 98%) has been developed. This unprecedented transformation employs NaN3 and DMF as N- and O-nucleophiles respectively. The role of DMF as the O-source in the reaction has been unequivocally proven by 18O labelling studies.

Mn-Catalyzed Highly Efficient Aerobic Oxidative Hydroxyazidation of Olefins: A Direct Approach to β-Azido Alcohols

Sun, Xiang,Li, Xinyao,Song, Song,Zhu, Yuchao,Liang, Yu-Feng,Jiao, Ning

supporting information, p. 6059 - 6066 (2015/05/27)

(Chemical Equation Presented). An efficient Mn-catalyzed aerobic oxidative hydroxyazidation of olefins for synthesis of β-azido alcohols has been developed. The aerobic oxidative generation of azido radical employing air as the terminal oxidant is disclosed as the key process for this transformation. The reaction is appreciated by its broad substrate scope, inexpensive Mn-catalyst, high efficiency, easy operation under air, and mild conditions at room temperature. This chemistry provides a novel approach to high value-added β-azido alcohols, which are useful precursors of aziridines, β-amino alcohols, and other important N- and O-containing heterocyclic compounds. This chemistry also provides an unexpected approach to azido substituted cyclic peroxy alcohol esters. A DFT calculation indicates that Mn catalyst plays key dual roles as an efficient catalyst for the generation of azido radical and a stabilizer for peroxyl radical intermediate. Further calculation reasonably explains the proposed mechanism for the control of C-C bond cleavage or for the formation of β-azido alcohols.

From simple organobromides or olefins to highly value-added bromohydrins: A versatile performance of dimethyl sulfoxide

Song, Song,Huang, Xiaoqiang,Liang, Yu-Feng,Tang, Conghui,Li, Xinwei,Jiao, Ning

, p. 2727 - 2731 (2015/05/27)

A novel and efficient direct transformation of secondary bromides or olefins to highly value-added bromohydrins has been disclosed. Dimethyl sulfoxide (DMSO), a cheap and common solvent, performs its versatile role as a solvent, an essential oxidant, and also as an oxygen source in this bromohydrin synthesis.

One-pot combination of enzyme and Pd nanoparticle catalysis for the synthesis of enantiomerically pure 1,2-amino alcohols

Schrittwieser, Joerg H.,Coccia, Francesca,Kara, Selin,Grischek, Barbara,Kroutil, Wolfgang,D'Alessandro, Nicola,Hollmann, Frank

supporting information, p. 3318 - 3331 (2013/12/04)

One-pot combinations of sequential catalytic reactions can offer practical and ecological advantages over classical multi-step synthesis schemes. In this context, the integration of enzymatic and chemo-catalytic transformations holds particular potential for efficient and selective reaction sequences that would not be possible using either method alone. Here, we report the one-pot combination of alcohol dehydrogenase-catalysed asymmetric reduction of 2-azido ketones and Pd nanoparticle-catalysed hydrogenation of the resulting azido alcohols, which gives access to both enantiomers of aromatic 1,2-amino alcohols in high yields and excellent optical purity (ee >99%). Furthermore, we demonstrate the incorporation of an upstream azidolysis and a downstream acylation step into the one-pot system, thus establishing a highly integrated synthesis of the antiviral natural product (S)-tembamide in 73% yield (ee >99%) over 4 steps. Avoiding the purification and isolation of intermediates in this synthetic sequence leads to an unprecedentedly low ecological footprint, as quantified by the E-factor and solvent demand.

Non-enzymatic kinetic resolution of 1,2-azidoalcohols using a planar-chiral DMAP derivative catalyst

Mesas-Sánchez, Laura,Díaz-álvarez, Alba E.,Dinér, Peter

, p. 753 - 757 (2013/07/27)

Optically pure 1,2-azidoalcohols are widely used as precursors for other high value organic products. A non-enzymatic kinetic resolution procedure for the stereoselective synthesis of chiral 1,2-azidoalcohols from the readily available racemic counterpart

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