1449247-10-2Relevant academic research and scientific papers
Syntheses of 5′-O-desmethylterphenyllin and related p-terphenyls and their inhibitory activity of TNF-α release from RBL-2H3 cells
Yajima, Arata,Urao, Shota,Yoshioka, Yasukiyo,Abe, Naoki,Katsuta, Ryo,Nukada, Tomoo
, p. 4986 - 4989 (2013)
The first total syntheses of 5′-O-desmethylterphenyllin and three related p-terphenyls have been achieved. The methodology features a Suzuki-Miyaura coupling reaction with a hindered aryl chloride as the key step. Two of the four synthesized 5′-O-desmethylterphenyllins exhibit moderate TNF-α release-inhibitory activity toward RBL-2H3 cells.
