2''-Desethyl-2''-vinyl Simvastatin, also known as Simvastatin EP Impurity G, is a derivative of the cholesterol-lowering drug Simvastatin (S485000). It is characterized by the absence of an ethyl group at the 2'' position and the presence of a vinyl group at the same position. This modification in the molecular structure may result in altered pharmacological properties compared to the parent compound.
1449248-72-9
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Basic information
- Product Name: 2’’-Desethyl-2’’-vinyl Simvastatin
- Synonyms: 2’’-Desethyl-2’’-vinyl Simvastatin;(1S,3R,7S,8S)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbut-3-enoateMethylene simvastatin
- CAS NO:1449248-72-9
- Molecular Formula: C25H36O5
- Molecular Weight: 416.55
- EINECS: N/A
- Product Categories: Chiral Reagents;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 569.9±50.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.12±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: -20°C Freezer, Under Inert Atmosphere
- Solubility: Acetone (Slightly), Chloroform (Slightly), Ethyl Acetate (Slightly)
- PKA: 13.49±0.40(Predicted)
- CAS DataBase Reference: 2’’-Desethyl-2’’-vinyl Simvastatin(CAS DataBase Reference)
- NIST Chemistry Reference: 2’’-Desethyl-2’’-vinyl Simvastatin(1449248-72-9)
- EPA Substance Registry System: 2’’-Desethyl-2’’-vinyl Simvastatin(1449248-72-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1449248-72-9(Hazardous Substances Data)
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1449248-72-9 Usage
Uses
Used in Pharmaceutical Industry:2''-Desethyl-2''-vinyl Simvastatin is used as an impurity in the manufacturing process of Simvastatin. It is essential to monitor and control the levels of this impurity to ensure the safety, efficacy, and quality of the final drug product. The presence of impurities can affect the drug's performance, stability, and potential side effects, making it crucial to maintain strict quality control standards during the production of Simvastatin.
Additionally, 2''-Desethyl-2''-vinyl Simvastatin may be used as a research compound for studying the effects of structural modifications on the pharmacological properties of statins. This can contribute to the development of new drugs with improved efficacy and safety profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 1449248-72-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,9,2,4 and 8 respectively; the second part has 2 digits, 7 and 2 respectively.Calculate Digit Verification of CAS Registry Number 1449248-72:
(9*1)+(8*4)+(7*4)+(6*9)+(5*2)+(4*4)+(3*8)+(2*7)+(1*2)=189
189 % 10 = 9
So 1449248-72-9 is a valid CAS Registry Number.
1449248-72-9 Well-known Company Product Price
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USP
(1428229) Methylene Simvastatin United States Pharmacopeia (USP) Reference Standard
1449248-72-9
1428229-30MG
14,500.98CNY
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1449248-72-9Upstream product
1449248-72-9Downstream Products
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2’’-Desethyl-2’’-vinyl Simvastatin
