1449291-61-5

Basic information

• Product Name: 4-borono-2-(1-hydroxyethyl)-6-(trimethylsilyl)benzoic acid
• Synonyms: 4-borono-2-(1-hydroxyethyl)-6-(trimethylsilyl)benzoic acid
• CAS NO: 1449291-61-5
• Molecular Weight: 282.176
• Mol File: 1449291-61-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-borono-2-(1-hydroxyethyl)-6-(trimethylsilyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-borono-2-(1-hydroxyethyl)-6-(trimethylsilyl)benzoic acid(1449291-61-5)
• EPA Substance Registry System: 4-borono-2-(1-hydroxyethyl)-6-(trimethylsilyl)benzoic acid(1449291-61-5)

Safety Data

• Hazardous Substances Data: 1449291-61-5(Hazardous Substances Data)

Upstream product

• 1104637-53-7 B-ethynyl N-methyliminodiacetic acid boronate 
• 1449291-63-7 but-3-yn-2-yl 3-(trimethylsilyl)propiolate 

Relevant articles and documents

Aryl N-methyliminodiacetic acid (MIDA) boronates from cyclotrimerization of ethynyl MIDA boronate with diynes

Cyclotrimerizations of ethynyl N-methyliminodiacetic acid (MIDA) boronate (1) with 1,6-diynes 2 have been studied, using three different catalysts (based on ruthenium, rhodium, and iridium) and variable reaction conditions. Successful cyclotrimerization reactions were obtained with both Cp*RuCl(cod) and Rh(cod)2BF4/BINAP as pre-catalysts in THF or acetone. Ruthenium-catalyzed cyclotrimerization of an unsymmetrically bromo-substituted diyne (2f) with 1 was successfully scaled up (2 g) and included in a total synthesis strategy toward potential selective inhibitors of tyrosine kinase 2.