1449385-18-5Relevant academic research and scientific papers
Potent activity against multidrug-resistant Mycobacterium tuberculosis of α-mangostin analogs
Sudta, Pichit,Jiarawapi, Payung,Suksamrarn, Apichart,Hongmanee, Poonpilas,Suksamrarn, Sunit
, p. 194 - 203 (2013/04/10)
A new series of mangostin analogs of natural α-mangostin from mangosteen was prepared and their antimycobacterial activity was evaluated in vitro against Mycobacterium tuberculosis H37Ra. The results showed that the monoalkyl tetrahydro α-mangostin analogs displayed increased antimycobacterial activity as compared with the lead natural xanthone, α-mangostin. Among the tested compounds, 6-methoxytetrahydro α-mangostin (16) exhibited the most potent antimycobacterial activity with minimum inhibitory concentration (MIC) of 0.78 μg/mL. The activity of the monoalkylated and monoacylated tetrahydro α-mangostins decreases as the length of carbon chain increases. The methyl ether analog was also active against the multidrug- resistant (MDR) strains with pronounced MICs of 0.78-1.56 μg/mL.
