1449386-50-8

Basic information

• Product Name: 4-(4-chlorophenyl)-3-(naphthalene-2-yl)pyrrolidin-2-one
• Synonyms: 4-(4-chlorophenyl)-3-(naphthalene-2-yl)pyrrolidin-2-one
• CAS NO: 1449386-50-8
• Molecular Weight: 321.806
• Mol File: 1449386-50-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-chlorophenyl)-3-(naphthalene-2-yl)pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-chlorophenyl)-3-(naphthalene-2-yl)pyrrolidin-2-one(1449386-50-8)
• EPA Substance Registry System: 4-(4-chlorophenyl)-3-(naphthalene-2-yl)pyrrolidin-2-one(1449386-50-8)

Safety Data

• Hazardous Substances Data: 1449386-50-8(Hazardous Substances Data)

Upstream product

• 101671-01-6 1-nitro-2-(4-chlorophenyl)ethylene 
• 1459756-95-6 methyl 3-(4-chlorophenyl)-2-(naphthalen-2-yl)-4-nitrobutanoate 
• 104-88-1 4-chlorobenzaldehyde 
• 581-96-4 2-naphthylacetic acid 
• 2876-71-3 methyl 2-naphthylacetate 

Relevant articles and documents

Synthesis and biological evaluation of novel 3,4-diaryl lactam derivatives as triple reuptake inhibitors This article is dedicated to Professor Jahyo Kang for his lifelong commitment to mentoring graduate students

A series of 3,4-diarylpyrrolidin-2-one was designed, prepared and evaluated as triple reuptake inhibitors for antidepressant. Most compounds exhibited comparable in vitro efficacy as norepinephrine and dopamine transporter reuptake inhibitors. Especially, 2i showed better potency than GBR-12909 (IC 50 = 14 nM) which was used as reference compound for dopamine transporter. In addition, 2a and 2b showed inhibition (5.17 μM-85.6 nM) for three transporters.