1449389-85-8Relevant articles and documents
Electrochemical HI-mediated Intermolecular C-N Bond Formation to Synthesize Imidazoles from Aryl Ketones and Benzylamines
Yang, Zan,Zhang, Jiaqi,Hu, Liping,Li, An,Li, Lijun,Liu, Kun,Yang, Tao,Zhou, Congshan
, p. 5952 - 5958 (2020/05/22)
An efficient and novel electrochemical oxidative tandem cyclization of aryl ketones and benzylamines for the synthesis of 1,2,4-trisubstituted-(1H)-imidazoles has been developed under metal- and oxidant-free conditions. This direct C-N bond formation strategy, with a broad functional group tolerance, affords the desired imidazoles in moderate to excellent yields.
Practical synthesis of polysubstituted imidazoles via iodine- Catalyzed aerobic oxidative cyclization of aryl ketones and benzylamines
Huang, Huawen,Ji, Xiaochen,Wu, Wanqing,Jiang, Huanfeng
, p. 170 - 180 (2013/03/13)
A practical synthetic method for polysubstituted imidazoles via iodine-catalyzed aerobic oxidative cyclization of aryl ketones and benzylamines has been developed. It was found to tolerate a broad range of substrates to prepare polysubstituted imidazole derivatives in a one-pot manner, and thus importantly allowed product diversity for imidazole chemistry. Additionally, the resultant 1,2,4-trisubstituted imidazoles could be conveniently transformed to functionalized 1,2,4,5-tetrasubstituted imidazoles via electrophilic substitution or direct C-H functionalization, or 2,4-diaryl-1H-imidazoles by debenzylation reaction, which further indicates potential applications of this method in synthetic and pharmaceutical chemistry. Copyright