144939-83-3 Usage
Molecular structure
A complex compound with multiple functional groups and stereochemistry.
15,19-Epoxy ring
A three-membered ring with two oxygen atoms and one carbon atom.
Pyrido ring
A six-membered nitrogen-containing aromatic ring.
1,4oxaazacyclotricosine ring
A 24-membered macrocyclic lactone ring with oxygen and nitrogen atoms.
Hydroxyl groups
Two or more OH groups present in the molecule.
Methoxy groups
Two or more OCH3 groups present in the molecule.
8-Ethyl side chain
An alkyl chain with eight carbon atoms attached to the main structure.
1-Methylethenyl side chain
A double-bonded carbon atom with a methyl group attached to the main structure.
4-Hydroxy-3-methoxycyclohexyl moiety
A cyclohexane ring with hydroxyl and methoxy groups at the 4 and 3 positions, respectively.
(1E) stereochemistry
The configuration of the double bond in the 1-methylethenyl side chain.
(1R,3R,4R) stereochemistry
The spatial arrangement of the substituents on the cyclohexane ring.
(14,16) positions
The locations of the methoxy groups on the 1,4oxaazacyclotricosine ring.
Pharmaceutical or biological activities
The potential for 15,19-Epoxy-3H-pyrido2,1-c1,4oxaazacyclotricosine-1,7,21(4H,8H,23H)-trione, 8-ethyl-5,6,11,12,13,14,15,16,17,18,19,20,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(1E)-2-(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl-1-methylethenyl-14,16-dimethoxy-4,10,12,18-te to have therapeutic or biological effects.
Structural diversity
The presence of various functional groups and stereochemistry within the molecule.
Check Digit Verification of cas no
The CAS Registry Mumber 144939-83-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,9,3 and 9 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 144939-83:
(8*1)+(7*4)+(6*4)+(5*9)+(4*3)+(3*9)+(2*8)+(1*3)=163
163 % 10 = 3
So 144939-83-3 is a valid CAS Registry Number.
144939-83-3Relevant academic research and scientific papers
Baumann, Karl,Knapp,Strnadt,Schulz,Grassberger
, p. 7761 - 7764 (1999)
Treatment of ascomycin or its O-TBDMS-derivatives with hydrogen sulfide and pyridine in dimethylformamide solution results in deoxygenation reactions at the tricarbonyl sequence of the binding domain. 9-deoxo-ascomycins (5a-c) are obtained in high yields
Synthesis of Derivatives of FK 506 and FR 900520: Modifications at the Binding Domain
Emmer, Gerhard,Weber-Roth, Sabine
, p. 5861 - 5874 (2007/10/02)
The synthesis of 9-deoxo-FK 506 (13a), 9-deoxo-FR 900520 (13b), 9-deoxo-10(R)-deoxy-FR900520 (14) and its 10(S) isomer 15 is described.Radical deoxygenation/elimination of the 9-dihydro-9,10-thiocarbonates 5a,5b,6a and 6b gave the 9,10 unsaturated compoun
