1449406-13-6

Basic information

• Product Name: C₂₈H₃₃ClNO₃Ru
• CAS NO: 1449406-13-6
• Molecular Weight: 568.098
• Mol File: 1449406-13-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₃₃ClNO₃Ru(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₃₃ClNO₃Ru(1449406-13-6)
• EPA Substance Registry System: C₂₈H₃₃ClNO₃Ru(1449406-13-6)

Safety Data

• Hazardous Substances Data: 1449406-13-6(Hazardous Substances Data)

Upstream product

• 52462-29-0 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 
• 1173933-75-9 [(1S,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol 

Relevant articles and documents

Anticancer activity of ruthenium(II) arene complexes bearing 1,2,3,4-tetrahydroisoquinoline amino alcohol ligands

Ruthenium complexes offer potential reduced toxicity compared to current platinum anticancer drugs. 1,2,3,4-tetrahydrisoquinoline amino alcohol ligands were synthesised, characterised and coordinated to an organometallic Ru(II) centre. These complexes were evaluated for activity against the cancer cell lines MCF-7, A549 and MDA-MB-231 as well as for toxicity in the normal cell line MDBK. They were observed to be moderately active against only the MCF-7 cells with the best IC50 value of 34 μM for the cis-dia-stereomeric complex C4. They also displayed excellent selectivity by being relatively inactive against the normal MDBK cell line with SI values ranging from 2.3 to 7.4.