1449415-08-0Relevant academic research and scientific papers
Fibrous networks with incorporated macrocycles: A chiral stimuli-responsive supramolecular supergelator and its application to biocatalysis in organic media
Qi, Zhenhui,Wu, Changzhu,Malo De Molina, Paula,Sun, Han,Schulz, Andrea,Griesinger, Christian,Gradzielski, Michael,Haag, Rainer,Ansorge-Schumacher, Marion B.,Schalley, Christoph A.
, p. 10150 - 10159 (2013)
A new and versatile, crown ether appended, chiral supergelator has been designed and synthesized based on the bis-urea motif. The introduction of a stereogenic center improved its gelation ability significantly relative to its achiral analogue. This low-molecular-weight gelator forms supramolecular gels in a variety of organic solvents. It is sensitive to multiple chemical stimuli and the sol-gel phase transitions can be reversibly triggered by host-guest interactions. The gel can be used to trap enzymes and release them on demand by chemical stimuli. It stabilizes the microparticles in Pickering emulsions so that enzyme-catalyzed organic reactions can take place in the polar phase inside the microparticles, the organic reactants diffusing through the biphasic interface from the surrounding organic phase. Because of the higher interface area between the organic and polar phases, enzyme activity is enhanced in comparison with simple biphasic systems. Supramolecular gels: A versatile, crown ether substituted, chiral bis-urea gelator forms gels in a variety of organic solvents. The gel is sensitive to multiple chemical stimuli and the reversible sol-gel phase transitions can be triggered by host-guest interactions. The supramolecular gel can be used for enzyme immobilization and stimuli-induced release (see figure). When used in Pickering emulsions containing nanoparticle-stabilized gel microparticles with a polar inner phase, the gelator broadens the range of solvents in which enzymes can be used to catalyze reactions in nonpolar media. Copyright
