1449420-99-8Relevant articles and documents
A room temperature copper catalyzed N-selective arylation of β-amino alcohols with iodoanilines and aryl iodides
Das, Priyabrata,De Brabander, Jef K.
, p. 7646 - 7652 (2013/08/23)
An efficient method is described for the synthesis of N-(2-aminophenyl)-2- hydroxyethylamines via a copper catalyzed N-selective arylation of β-amino alcohols with iodoanilines. The corresponding coupling products are useful intermediates for the synthesis of a variety of N-2-hydroxyethyl-substituted benzimidazoles, benzimidazolones, and iminobenzimidazoles. We found that 2-iodoaniline only arylates certain amino alcohols but not amines lacking a hydroxyl group. We also demonstrate the arylation of sterically demanding β-amino alcohols, such as ephedrine and prolinol with aryl iodides at room temperature.
