1449477-00-2

Upstream product

• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 104-87-0 4-methyl-benzaldehyde 
• 106-49-0 p-toluidine 
• 1388114-45-1 9-methyl-7-p-tolyl-7,12-dihydro-6H-chromeno[4,3-b]quinolin-6-one 

Relevant academic research and scientific papers

Molecular iodine catalysed one-pot synthesis of chromeno[4,3-b]quinolin-6-ones under microwave irradiation

We demonstrate a facile one pot approach for the regioselective synthesis of chromeno[4,3-b]quinolin-6-one derivatives in excellent yields under microwave (MW) irradiation. This transformation presumably proceeds via a three-component tandem annulation of

Synthesis and antitumor activity of novel coumarin derivatives via a three-component reaction in water

An efficient synthesis of novel coumarin derivatives via a three-component condensation of 4-hydroxycoumarin, aldehydes and aromatic amines catalyzed by sulfonic acid functionalized ionic liquid L-2-(hydroxymethyl)-1-(4-sulfobutyl) pyrrolidinium hydrogen sulfate ([HYSBPI]·HSO4) is reported. The condensed product was obtained with excellent yields in water under microwave irradiation condition. The antitumor activities of all the synthesized compounds were assessed on two different human cancer cell lines (A-549 and MCF-7), and the results showed that these compounds had weak-to-good antitumor activities and their IC50 ranged from 0.05 to more than 100 μmol·L-1. An efficient synthesis of novel coumarin derivatives via a three-component condensation of 4-hydroxycoumarin, aldehydes and aromatic amines catalyzed by sulfonic acid functionalized ionic liquid L-2-(hydroxymethyl)-1-(4-sulfobutyl) pyrrolidinium hydrogen sulfate [HYSBPI]·HSO4 is reported. The condensed product was obtained with excellent yields in water under microwave irradiation condition. The antitumor activities of all the synthesized compounds were assessed on two different human cancer cell lines (A-549 and MCF-7), and the results showed that these compounds had weak-to-good antitumor activities and their IC50 ranged from 0.05 to more than 100 μmol·L-1.