1449487-98-2Relevant academic research and scientific papers
Microwave-assisted one-pot synthesis of substituted 3-bromoimidazo[1,2 -A]pyridines and imidazoheterocycles
Patil, Shashikant M.,Mascarenhas, Malcolm,Sharma, Rajiv,Mohana Roopan,Roychowdhury, Abhijit
, p. 1509 - 1515 (2015/04/27)
Herein, an efficient, one-pot microwave-assisted synthesis of a diverse set of 3-bromoimidazo[1,2-a]pyridines is being reported with good yields (40-85%). The method involves electrophilic aromatic bromination using bromodimethylsulfonium ion generated in situ via oxidation of HBr salt by DMSO. This methodology was also applied to the synthesis of related imidazoheterocycles.
DMSO-POCl3: A reagent for methylthiolation of imidazo[1,2-a]pyridines and other imidazo-fused heterocycles
Patil, Shashikant M.,Kulkarni, Sarang,Mascarenhas, Malcolm,Sharma, Rajiv,Roopan, S. Mohana,Roychowdhury, Abhijit
, p. 8255 - 8262 (2013/09/02)
A practical and metal free method for methylthiolation of imidazo[1,2-a]pyridines and other imidazo-fused heterocycles using DMSO-POCl3 complex is reported. The reactions are carried out at room temperature that give the corresponding methylthiolated products in good to excellent yield. Further, its application to indole has been demonstrated.
