1449488-16-7Relevant academic research and scientific papers
Titanium-mediated reductive cross-coupling reactions of imines with terminal alkynes: An efficient route for the synthesis of stereodefined allylic amines
Mao, Kebin,Fan, Guoqin,Liu, Yuanhong,Li, Shi,You, Xu,Liu, Dan
, p. 621 - 627 (2013)
Low-valency titanium species, generated in situ by using Ti(OiPr) 4/2 c-C5H9 MgCl reagent, react with imines to give a titanium-imine complex that can couple with terminal alkynes to provide azatitanacyclopentenes with excellent regioselectivity. Stereo-defined allylic amines are obtained in good yields after hydrolysis or iodonolysis of the corresponding azatitanacyclopentenes. When ethynylcyclopropane is used as the coupling partner to react with imines in this reaction, the initially generated allylic amine undergoes an unexpected 1,3-amino migration on silica gel during the column chromatography.
