1449498-83-2

Upstream product

• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 1301261-30-2 C₂₀H₃₉NO₄Si 
• 1574312-06-3 (S)-tert-butyl 4-[(R)-1-{(tert-butyldimethylsilyl)oxy}-3-oxopropyl]-2,2-dimethyloxazolidine-3-carboxylate 
• 1449498-82-1 (2Z,5R,6S)-6-amino-5,7-bis{(tert-butyldimethylsilyl)oxy}hept-2-en-1-yl methyl carbonate 
• 1574312-07-4 (S)-tert-butyl 4-[(R,Z)-1-{(tert-butyldimethylsilyl)oxy}-5-hydroxypent-3-en-1-yl]-2,2-dimethyloxazolidine-3-carboxylate 
• 1574312-09-6 (S)-tert-butyl 2,2-dimethyl-4-{(R,Z)-11,11,12,12-tetramethyl-3-oxo-2,4,10-trioxa-11-silatridec-6-en-9-yl}oxazolidine-3-carboxylate 

Downstream Products

• 1449498-68-3 (2S,3R,5S)-3-{(tert-butyldimethylsilyl)oxy}-2-[{(tert-butyldimethylsilyl)oxy}methyl]-1-{(2-nitrophenyl)sulfonyl}-5-vinylpyrrolidine 
• 1449498-67-2 (2S,3R,5R)-3-{(tert-butyldimethylsilyl)oxy}-2-[{(tert-butyldimethylsilyl)oxy}methyl]-1-{(2-nitrophenyl)sulfonyl}-5-vinylpyrrolidine 

Relevant academic research and scientific papers

Asymmetric synthesis of 2,5-disubstituted 3-hydroxypyrrolidines based on stereodivergent intramolecular iridium-catalyzed allylic aminations

Intramolecular iridium-catalyzed allylic aminations of homochiral (E)-6-N-nosylaminohept-2-en-1-yl methyl carbonates were investigated. The relative position of the 2,5-substituents of the resulting pyrrolidines was found to be controlled by using both enantiomers (4 and 5) of the appropriate chiral ligand, demonstrating a simple and highly stereodivergent synthetic protocol. Selected trans- and cis-2,5-disubstituted 3-hydroxypyrrolidines (2a and 18a) were converted to (+)-bulgecinine (6) and (+)-preussin (7), respectively.

Asymmetric synthesis of 1-alkyl-2-deoxyiminofuranoses via the iridium-catalyzed intramolecular cyclization of an allylic carbonate

An asymmetric synthesis of 1-alkyl-2-deoxyiminofuranoses was achieved in which the Ir-catalyzed intramolecular cyclization was the key step. The diastereoselective cyclization converted an allylic carbonate into pyrrolidine derivatives. The a-glucosidase inhibitory activities of the prepared 2-deoxyiminofuranoses were also investigated.