14495-28-4 Usage
Uses
Used in Research Studies:
(5alpha)-4,4,14-trimethylpregn-8-ene-3,20-dione is used as a research compound for studying the effects and mechanisms of androgenic steroids. Its potent androgenic properties make it a valuable tool in understanding the role of these hormones in various physiological processes.
Used in Medicinal Applications:
As a synthetic derivative of testosterone, (5alpha)-4,4,14-trimethylpregn-8-ene-3,20-dione is used as a pharmaceutical compound for the development of medications targeting androgen-related conditions. Its androgen receptor agonist activity may contribute to the treatment of conditions such as androgen deficiency or hormone-related disorders.
Used in Hormone Replacement Therapy:
(5alpha)-4,4,14-trimethylpregn-8-ene-3,20-dione is used as a hormone precursor in hormone replacement therapy. Its potential to modulate androgen levels makes it a candidate for treating conditions related to hormonal imbalances, such as menopause or andropause.
Used in Sports Performance Enhancement:
Due to its potent androgenic properties, (5alpha)-4,4,14-trimethylpregn-8-ene-3,20-dione may be used as a performance-enhancing substance in sports. However, it is important to note that the use of such substances is often prohibited in professional sports due to their potential health risks and the desire to maintain a level playing field among athletes.
Used in Veterinary Medicine:
In the veterinary field, (5alpha)-4,4,14-trimethylpregn-8-ene-3,20-dione may be used as a hormone supplement or for treating hormone-related conditions in animals. Its androgenic properties could be beneficial in managing conditions such as reproductive issues or hormone imbalances in pets and livestock.
Check Digit Verification of cas no
The CAS Registry Mumber 14495-28-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,4,9 and 5 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 14495-28:
(7*1)+(6*4)+(5*4)+(4*9)+(3*5)+(2*2)+(1*8)=114
114 % 10 = 4
So 14495-28-4 is a valid CAS Registry Number.
14495-28-4Relevant academic research and scientific papers
Cationic Cyclization of a Substrate Having an Internal Acetylenic Bond. Synthesis of Euphol and Tirucallol
Bartlett, William R.,Johnson, William S.,Plummer, Mark S.,Small, Vernon R.
, p. 2215 - 2224 (2007/10/02)
New methodological studies directed toward the synthesis of tetracyclic triterpenoids bearing the 8,9-olefinic bond involve the acid-catalyzed cyclization of the dienediynol 9 as the key step.Surprisingly the ring closure, giving mainly 10, leads to the euphane rather than the lanostane ring system ( see Scheme I).This discovery has made possible the first synthesis of euphol as well as its C-20 epimer tirucallol.New methodology was developed for the highly stereoselective production of tetrasubstituted olefinic bonds during the synthesis of the pro-C-13,14 olefinic bond of cyclization substrate 9 ( Scheme II).The constitution of ketone 10 was established by conversion into the dione 30 as shown in Scheme III.This racemic material was rigorously identified with the natural enantiomer, prepared by degradation of euphol.Dione l-30, obtained by degradation of the natural product was used for reconstruction of the C-17 side chaine to give euphol (1a) and tirucallol (1c); thus a formal totally synthesic pathway to these products has been established.
