1449574-78-0Relevant articles and documents
Chiral Vanadyl(V) Complexes Enable Efficient Asymmetric Reduction of β-Ketoamides: Application toward (S)-Duloxetine
Chen, Chien-Tien,Maity, Nabin Ch.,Agarwal, Rachit,Lai, Chien-Fu,Liao, Yiya,Yu, Wei-Ru
, p. 6408 - 6419 (2020)
High-valent chiral oxidovanadium(V) complexes derived from 3,5-substituted-N-salicylidene-l-tert-leucine were used as catalysts in asymmetric reduction of N-benzyl-β-ketoamides. Among six different solvents, three different alcohol additives, and two different boranes examined, the use of pinacolborane in tetrahydrofuran (THF) with a t-BuOH additive led to the best results at -20 °C. The corresponding β-hydroxyamides can be furnished with yields up to 92percent and an enantiomeric excess (ee) up to 99percent. We have successfully extended this catalytic protocol for the synthesis of an (S)-duloxetine precursor.
Copper salts as additives in gold(I)-Catalyzed reactions
Guerinot, Amandine,Fang, Weizhen,Sircoglou, Marie,Bour, Christophe,Bezzenine-Lafollee, Sophie,Gandon, Vincent
supporting information, p. 5848 - 5852 (2013/07/11)
The right combination: CuI and CuII salts can advantageously replace silver additives in AuI-catalyzed reactions. On the basis of reactivity studies and NMR experiments, it is believed that anion metathesis between CuYn (Y=OTf, BF4, PF6, SbF6) and [R3PAuCl] takes place to give [R 3PAu]Y. As this process is slow, there is no fast decay of the active species, thus allowing large-scale reactions, even at high temperatures, with low loadings of the gold complex. Copyright
