1449581-67-2Relevant academic research and scientific papers
Amide activation by TMSCl: Reduction of amides to amines by LiAlH 4 under mild conditions
Ravinder,Rajeswar Reddy,Panasa Reddy,Bandichhor, Rakeshwar
supporting information, p. 4908 - 4913 (2013/08/28)
An expeditious and practical method for the reduction of amides to amines is reported. The method consists of activation of amides with TMSCl followed by reduction with LiAlH4. Various amides/lactams including hindered amides and secondary amides gave the corresponding amines in good to excellent yields. This novel protocol has a wide substrate scope and shows good functional group tolerance with high stereoretention.
