144965-45-7

Upstream product

• 50997-19-8 N-(cis-β-Carboxy-acryloyl)-(L)-phenylalaninmethylester 
• 2577-90-4 L-phenylalanine methyl ester 
• 144965-41-3 N-(cis-β-Benzyloxycarbonyl-acryloyl)-(L)-phenylalaninmethylester 
• 100-46-9 benzylamine 
• 50997-19-8 N-(cis-β-Carboxy-acryloyl)-(D)-phenylalaninmethylester 
• 2577-90-4 (D)-Phenylalaninmethylester 
• 144965-41-3 N-(cis-β-Benzyloxycarbonyl-acryloyl)-(D)-phenylalaninmethylester 

Relevant academic research and scientific papers

Synthetic and NMR-Spectroscopic Investigation of Benzylamine Addition to N-Maleylamino Acid Derivatives

During the addition of amines to maleylamino acids in general β-amino derivatives are formed.In order to change the reactivity within the vinylogous maleyl system we introduced the β-benzylester group into the starting compound N-(cis-β-carboxyacryloyl)-phenylalanine methylester 1.The obtained benzylester 2 is adding benzylamine in α-position yielding N-benzyl-α-aspartyl(β-benzyl)-phenylalanine methylester 4.The addition reaction was investigated by 1H-NMR-spectroscopy.The structures of the compounds have been confirmed by elemental analysis, IR, 1H-NMR and 13C-NMR spectroscopy.Keywords. α-Aspartyl peptides; N-Maleylamino acid derivatives; Nucleophilic addition.