1449693-12-2

Upstream product

• 1436426-79-7 1-(5-chloro-2-nitrophenyl)-4-(3,3,3-trifluoropropyl)piperazine 
• 462073-61-6 1-(5-chloro-2-nitrophenyl)piperazine 
• 700-37-8 4-chloro-2-fluoro-nitrobenzene 
• 1436426-84-4 4-((tert-butoxycarbonylamino)methyl)-2,3-difluorobenzoic acid 
• 1436426-74-2 ethyl 4-(aminomethyl)-2,3-difluorobenzoate 
• 773135-56-1 ethyl 2,3-difluoro-4-methylbenzoate 
• 1436426-83-3 ethyl 4-(bromomethyl)-2,3-difluorobenzoate 
• 1436426-21-9 4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)aniline 
• 1436426-38-8 4-((tert-butoxycarbonylamino)methyl)-2,3-difluorobenzoic acid 

Downstream Products

• 1436422-32-0 4-(aminomethyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide 
• 1436423-02-7 tert-butyl 4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzylcarbamoyl)piperidine-1-carboxylate 
• 1436423-50-5 N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluoro-4-((2-hydroxyacetamido)methyl)benzamide 
• 1436423-29-8 (R)-N-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)thiomorpholine-3-carboxamide 
• 1436423-27-6 (R)-tert-butyl 3-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzylcarbamoyl)thiomorpholine-4-carboxylate 
• 1436424-53-1 N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluoro-4-((2-(4-(hydroxymethyl)piperidin-1-yl)acetamido)methyl)benzamide 
• 1436424-66-6 4-((2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)acetamido)methyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide 

Relevant academic research and scientific papers

MODULATORS OF THE G PROTEIN-COUPLED MAS RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO

The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salts, solvates, and hydrates thereof that are useful in methods of treatment and alleviation of diseases and disorders of the heart, brain, kidney, immune, and reproductive system resulting from ischemia, or reperfusion subsequent to ischemia, and any downstream complication(s) related thereto. The present invention further relates to methods of treatment and alleviation of diseases and disorders of the vasculature resulting from vasoconstriction or hypertension and any downstream complication(s) resulting from elevated blood pressure and/or reduced tissue perfusion.