1449702-45-7Relevant academic research and scientific papers
Ni-catalyzed reductive coupling of alkyl acids with unactivated tertiary alkyl and glycosyl halides
Zhao, Chenglong,Jia, Xiao,Wang, Xuan,Gong, Hegui
supporting information, p. 17645 - 17651 (2015/02/05)
This work highlights Ni-catalyzed reductive coupling of alkyl acids with alkyl halides, particularly sterically hindered unactivated tertiary alkyl bromides for the production of all carbon quaternary ketones. The reductive strategy is applicable to α-selective synthesis of saturated, fully oxygenated C-acyl glycosides through easy manipulations of the readily available sugar bromides and alkyl acids, avoiding otherwise difficult multistep conversions. Initial mechanistic studies suggest that a radical chain mechanism (cycle B, Scheme 1) may be plausible, wherein MgCl2 promotes the reduction of NiII complexes.
Osmium catalyst for the borrowing hydrogen methodology: α-alkylation of arylacetonitriles and methyl ketones
Buil, Maria L.,Esteruelas, Miguel A.,Herrero, Juana,Izquierdo, Susana,Pastor, Isidro M.,Yus, Miguel
, p. 2072 - 2075 (2013/09/24)
Complex [Os(η6-p-cymene)(OH)(IPr)]OTf is an efficient catalyst precursor for the α-alkylation of arylacetonitriles and methyl ketones with alcohols, which works with turnover frequencies between 675 and 176 h-1 for nitriles and between 194 and 28 h-1 for ketones.
