1449754-12-4

Upstream product

• 1427309-24-7 (3S,4R)-1-benzyl-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidine-3-carboxylic acid 
• 1427309-47-4 (4-methoxyphenyl)methyl (3R,4R)-1-benzyl-4-methylpyrrolidine-3-carboxylate 
• 1427058-85-2 (4-methoxyphenyl)methyl (3R,4R)-1-benzyl-4-methylpyrrolidine-3-carboxylate (-)-dibenzoyl-L-tartrate 
• 1427309-44-1 tert-butyl 4-[(3S,4R)-3-[2-(tert-butoxy)-2-oxoethyl]-1-{[2-chloro-6-(difluoromethyl)phenyl]methyl}-4-methylpyrrolidin-3-amido]piperidine-1-carboxylate 
• 1427058-75-0 2-(bromomethyl)-1-chloro-3-(difluoromethyl)benzene 
• 1379323-52-0 2-(bromomethyl)-3-chlorobenzaldehyde 
• 1379313-10-6 [2-(bromomethyl)-3-chlorophenyl]methanol 
• 188187-03-3 2-bromomethyl-3-chloro-benzoic acid methyl ester 
• 99586-84-2 methyl 2-methyl-3-chlorobenzoate 
• 7499-08-3 3-chloro-2-methylbenzoic acid 
• 1427058-67-0 tert-butyl 4-[(3S,4R)-3-[2-(tert-butoxy)-2-oxoethyl]-1-[(2,6-dichlorophenyl)methyl]-4-methylpyrrolidin-3-amido]piperidine-1-carboxylate 
• 1427309-32-7 tert-butyl 4-[(3S,4R)-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidin-3-amido]piperidine-1-carboxylate 
• 1427309-31-6 tert-butyl 4-[(3S,4R)-1-benzyl-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidin-3-amido]piperidine-1-carboxylate 

Downstream Products

• 1427058-40-9 2-[(3S,4R)-1-{[2-chloro-6-(difluoromethyl)phenyl]methyl}-3-{[1-(cyclohex-1-en-1-ylmethyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetic acid 

Relevant academic research and scientific papers

PYRROLIDINE-3-YLACETIC ACID DERIVATIVE

A compound represented by formula (1) or a pharmaceutically acceptable salt thereof has an inhibitory effect in the fractalkine-CX3CR1 pathway: wherein R represents a C1-6 alkyl group unsubstituted or having 1 to 3 substituents selected from Substituent Group A, a C3-8 cycloalkyl group unsubstituted or having 1 to 3 substituents selected from Substituent Group A, or a C3-8 cycloalkenyl group unsubstituted or having 1 to 3 substituents selected from Substituent Group A, X represents a C1-6 alkyl group, Y and Z are the same or different from each other and each represents a halogen atom or a C1-6 alkyl group unsubstituted or having 1 to 3 substituents selected from Substituent Group B, n represents 0 or 1, Substituent Group A consists of halogen atoms, and Substituent Group B consists of halogen atoms.