1449763-23-8

Basic information

• Product Name: (E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-N⁴-(4-trifluoromethoxybenzylidene)semicarbazide
• Synonyms: (E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-N⁴-(4-trifluoromethoxybenzylidene)semicarbazide
• CAS NO: 1449763-23-8
• Molecular Weight: 657.622
• Mol File: 1449763-23-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-N⁴-(4-trifluoromethoxybenzylidene)semicarbazide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-N⁴-(4-trifluoromethoxybenzylidene)semicarbazide(1449763-23-8)
• EPA Substance Registry System: (E)-N¹-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-N⁴-(4-trifluoromethoxybenzylidene)semicarbazide(1449763-23-8)

Safety Data

• Hazardous Substances Data: 1449763-23-8(Hazardous Substances Data)

Upstream product

• 58113-30-7 4-(3-chloropropoxy)-3-methoxyacetophenone 
• 1160707-44-7 1-[4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl]ethan-1-one 
• 1449763-02-3 1-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-(dimethylamino)propyl-2-en-1-one 
• 659-28-9 p-trifluoromethoxybenzaldehyde 
• 1449763-33-0 N¹-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)semicarbazide 
• 1394166-09-6 6-methyloxy-7-(4-(3-chloropropoxy))-4-4-hydroxyquinoline 
• 1167053-13-5 6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-ol, sodium salt 
• 205448-32-4 4-chloro-6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinoline 
• 960299-44-9 4-(3-((4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yl)oxy)propyl)morpholine 
• 479690-10-3 3-Fluoro-4-{[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy}-aniline 
• 1449763-30-7 phenyl 3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenylcarbamate 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 

Relevant articles and documents

Discovery and optimization of novel 4-phenoxy-6,7-disubstituted quinolines possessing semicarbazones as c-Met kinase inhibitors

A novel series of N1-(3-fluoro-4-(6,7-disubstituted-quinolin-4- yloxy)phenyl)-N4-arylidenesemicarbazide derivatives were synthesized and evaluated for their c-Met kinase inhibition and cytotoxicity against A549, HT-29, MKN-45 and MDA-MB-231 cancer cell lines in vitro. Several potent compounds were further evaluated against three other cancer cell lines (U87MG, NCI-H460 and SMMC7721). Most of compounds tested exhibited moderate to excellent activity. The studies of SARs identified the most promising compound 28 (c-Met IC50 = 1.4 nM) as a c-Met kinase inhibitor. In this study, a promising compound 28 was identified, which displayed 2.1-, 3.3-, 48.4- and 3.6-fold increase against A549, HT-29, U87MG and NCI-H460 cell lines, respectively, compared with that of Foretinib.