14499-33-3Relevant academic research and scientific papers
Synthesis of C3-alkenylated 2,3,4-trisubstituted pyrrole derivatives through cyclization of methylene isocyanides and ene-yne-ketones
Li, Shasha,Zeng, Gongruixue,Xing, Xiaoqi,Yang, Zhiheng,Ma, Feiyun,Li, Boxia,Cheng, Weiyan,Zhang, Jiankang,He, Ruoyu
, p. 1834 - 1837 (2021)
A mild, transition-metal-free and facile C3-alkenylated 2,3,4-trisubstituted pyrrole cyclization of methylene isocyanides with ene-yne-ketones in moderate to good yields was explored. The E-alkenylated products were isolated in moderate to exclusive selec
Preparation of 4-(Nitromethyl)furan Derivatives and Their Application in the Syntheses of Bis(furan-2-yl)oximes
Wan, Yinbo,Zhu, Yang,Peng, Haiyun,Deng, Guisheng
, p. 281 - 293 (2021/12/27)
An efficient method for the preparation of tetrasubstituted furans, which contains a nitromethyl group at the 4-position, has been developed. The applications of 4-(nitromethyl)furans on the synthesis of highly functionalized bis(furyl)oxime were explored
Phosphine-Mediated Dimerization of Conjugated Ene-Yne Ketones: Stereoselective Construction of Dihydrobenzofurans
Zhu, Cheng-Zhi,Sun, Yao-Liang,Wei, Yin,Shi, Min
, p. 1263 - 1270 (2017/04/18)
A new strategy for the phosphine-mediated dimerization of conjugated ene-yne ketones to produce functionalized dihydrobenzofurans has been developed, affording diversified 4,5-dihydrobenzofurans in moderate to excellent yields with high diastereoselectivities under mild conditions. This new synthetic method can tolerate a variety of functional groups and can be performed on a gram scale and in an asymmetric variant using the chiral phosphine Xyl-BINAP to give the desired products with up to 94% ee. (Figure presented.).
Facile synthesis of cyanofurans via Michael-addition/cyclization of ene-yne-ketones with trimethylsilyl cyanide
Yu, Yue,Chen, Yang,Wu, Wanqing,Jiang, Huanfeng
supporting information, p. 640 - 643 (2017/01/13)
We have developed a Michael-addition/cyclization procedure between ene-yne-ketones and TMSCN under metal-free conditions. A wide range of cyanofurans was delivered in high yields, which could be further transformed to a series of furo-furanimines, furo-pyridazines or carboxamido-furans. In addition, deuterium-labeling experiments have been conducted to clarify the reaction pathway.
Csp3-P versus Csp2-P bond formation: Catalyst-controlled highly regioselective tandem reaction of Ene-Yne-ketones with H-phosphonates
Yu, Yue,Yi, Songjian,Zhu, Chuanle,Hu, Weigao,Gao, Bingjie,Chen, Yang,Wu, Wanqing,Jiang, Huanfeng
supporting information, p. 400 - 403 (2016/02/18)
Under copper-catalyzed or base-promoted conditions, a wide range of ene-yne-ketones react with H-phosphonates to afford various phosphorylated furans in good yields. A copper carbene generation or a Michael addition is proposed as the key step in the sele
Copper-catalyzed C-O bond formation: An efficient one-pot highly regioselective synthesis of furans from (2-furyl)carbene complexes
Cao, Hua,Zhan, Haiying,Cen, Jinghe,Lin, Jingxin,Lin, Yuanguang,Zhu, Qiuxia,Fu, Minling,Jiang, Huanfeng
supporting information, p. 1080 - 1083 (2013/03/29)
A convenient one-pot Cu(I)-catalyzed strategy for regioselective synthesis of trisubstituted furan derivatives has been developed via (2-furyl) carbene complexes. This process has opened a new synthetic route to a variety of α-carbonyl furans using air as
Zinc-catalyzed synthesis of functionalized furans and triarylmethanes from enynones and alcohols or azoles: Dual X-H bond activation by zinc
Gonzalez, Jesus,Gonzalez, Javier,Perez-Calleja, Carmela,Lopez, Luis A.,Vicente, Ruben
supporting information, p. 5853 - 5857 (2013/06/27)
Ba'zinc'ga! A zinc-catalyzed sequence involving a cyclization with a subsequent C-O, C-N, or C-C bond formation enables the preparation of a variety of valuable furfuryl ethers (with alcohols) and unsymmetrically substituted triarylmethane derivatives (wi
