145-73-3

Usage

Uses

Used in Agricultural Industry:
ENDOTHAL is used as a defoliant and herbicide for the control of broad-leaved weeds and annual grass in vegetable crops. It is also employed as a cotton defoliant and as a selective contact herbicide on both terrestrial and aquatic weeds. The potassium and amine salts of ENDOTHAL are used as aquatic herbicides to control a variety of plants, including plankton, pondweed, niad, coontail, milfoil, elodea, and algaes in water bodies and rice fields. Additionally, ENDOTHAL is used to control annual grass and broadleaf weeds in sugar beets, spinach, and turf. It also reduces sucker branch growth in hops and acts as a desiccant to aid the harvest of alfalfa, potatoes, clover, and cotton. It is approved for use in the U.S. and other countries, but not in EU countries.
Used in Pharmaceutical Industry:
ENDOTHAL is used as an inhibitor of PP2A phosphatase activity and is also employed as a cell adhesion inhibitor.

Air & Water Reactions

Stable up to 90°C, above which ENDOTHAL undergoes slow hydrolysis.

Reactivity Profile

A phthalic acid derivative.

Hazard

Strong irritant to eyes and skin.

Trade name

ACCELERATE?; AQUATHOL?; DES-I-CATE?; HYDOUT?; HYDROTHAL-47?; HYDROTHOL?; NIAGARATHOL?; RIPENTHOL?; TRI-ENDOTHAL?

Safety Profile

Poison by ingestion. Very irritating to skin, eyes, and mucous membranes. Causes dlarrhea. When heatedto decomposition it emits acrid smoke and fumes

Potential Exposure

Endothall is dicarboxylic acid defoliant and herbicide used on both terrestrial and aquatic weeds.

Environmental Fate

Biological. Incubation of 14C-ring labeled endothall (10 mg/mL) by Arthrobacter sp., which was isolated from pond water and a hydrosol, in aerobic sediment-water suspensions revealed that after 30 days, 40% evolved as 14CO2. Glutamic acid was the major transformation product. Minor products were alanine, citric and aspartic acids and unidentified products, some of which were tentatively identified as phosphate esters (Sikka and Saxena, 1973). In pond water treated with endothall (2 and 4 ppm), detectable levels were found after 7 days (Sikka and Rice, 1973). Biodegradation was rapid in an Ontario soil sample. After 1 week, 70% of endothall added was converted to carbon dioxide (Simsiman et al., 1976). Chemical/Physical. Reacts with bases forming water-soluble salts. Above 90°C, endothall is slowly converted to the anhydride (Windholz et al., 1983; Hartley and Kidd, 1987) and water (Humburg et al., 1989). Endothall is stable to light (Hartley and Kidd, 1987).

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2588 Pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Incompatibilities

Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic, and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur)

Waste Disposal

Small quantities may be disposed of by burial in soil which is rich in organic matter. Large quantities are best disposed of by incineration. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (5100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office

InChI:InChI=1/C8H10O5/c9-7(10)5-3-1-2-4(13-3)6(5)8(11)12/h3-6H,1-2H2,(H,9,10)(H,11,12)

Upstream product

• 110-00-9 furan 
• 108-31-6 maleic anhydride 
• 3215-51-8 cis-endo-2,3-(biscarbomethoxy)-7-oxabicyclo<2.2.1>heptane 
• 4505-29-7 dimethyl 7-oxabicyclo<2.2.1>heptane-2β,3β-dicarboxylate 
• 81486-09-1 (2-endo,3-exo)-7-oxabicyclo<2.2.1>hept-5-ene-2,3-bis(carbonyl chloride) 
• 1829-60-3 dimethyl 7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate 
• 5629-08-3 (1S,3S,4R)-7-Oxa-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid 

Downstream Products

• 55423-53-5 (2-endo,3-exo)-7-oxabicyclo<2.2.1>heptane-2,3-dimethanol 
• 6253-24-3 hexahydro-4,7-epioxido-isoindole-1,3-dione 
• 97909-51-8 (2-endo,3-exo)-7-oxabicyclo<2.2.1>heptane-2,3-dimethanol bis(4-methylbenzenesulfonate) 

Related news

Desiccation of potato cultivars with ENDOTHAL (cas 145-73-3) and adjuvants09/28/2019

Desiccants are used in potato production to remove haulms prior to harvest to facilitate harvest. New formulations of the desiccant endothal were compared to diquat for potential as a top desiccant on four potato cultivars. Tubers were stored at 3 o C and 95% RH for determination of daug...detailed

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of demethylcantharidate-linked platinum(II) complexes of N-monoalkyl-1R,2R-diaminocyclohexane derivatives

Nine platinum(II) complexes with N-monoalkyl 1R,2R-DACH derivatives as carrier ligands and demethylcantharidate as a leaving group were synthesized and spectrally characterized. All the complexes showed considerable cytotoxicity against tested human cancer cell lines: A549, HCT116 HepG-2 and MCF7 cell lines. Especially, complex 2 exhibited potent cytotoxicity against A549 (1.01?μM) and HCT116 (0.83?μM) cell lines, and showed no cross-resistance to cisplatin against SGC7901/CDDP cell line (RF?=?1.44). In addition, the typical compounds were further studied by flow cytometric analysis and western blot method. The results indicated that they induced apoptosis by a mitochondrial-dependent pathway, which were similar to cisplatin.

Homogeneous, stable and flowable aqueous mixtures and dispersions of water-insoluble substances formulated therefrom exhibiting optical birefringence

Stable and flowable aqueous dispersions of at least one water-insoluble material are formulated by dispersing such water-insoluble material, e.g., solid particulates of a plant protection compound, into a homogeneous, stable and flowable aqueous composition that includes (1) at least one water-soluble derivative of a plant protection active agent bearing at least one ionizable functional group and at least one hydrophilic functional group, (2) at least one nonionic surface-active agent and/or at least one aliphatic, cycloaliphatic or arylaliphatic alcohol having from 4 to 15 carbon atoms, and (3) water, this composition exhibiting optical birefringence and a yield point of at least 0.1 pascal.

Substituted pyridinesulfonamide compound or its salt, process for preparing the same, and herbicide containing the same

A substituted pyridinesulfonamide compound or its salt represented by the following general formula (I): STR1 wherein A is CH or N; when A is CH, R1 and R2 may be either each independently a member selected from the group consisting of unsubstituted or substituted alkyl groups, unsubstituted or substituted alkenyl groups, unsubstituted or substituted cycloalkyl groups, and unsubstituted or substituted phenyl groups; when A is N, R1 is an unsubstituted or substituted alkyl group, R2 is an unsubstituted or substituted alkyl group, or an unsubstituted or substituted alkoxy group; and X and Y are each independently a member selected from the group consisting of alkyl groups and alkoxy groups, is disclosed. This compound is useful as the effective ingredient of a herbicide showing a wide weed-control spectrum even if used in a small amount.

Method of manufacturing a dry water-soluble herbicidal salt composition

A method of manufacturing a solid, water-soluble herbicidal composition comprising a water-soluble salt of a herbicidal compound is disclosed. The herbicidal compound is a water-insoluble compound that includes a carboxylic acid functionality, such as a phenoxy-substituted carboxylic acid compound or a substituted benzoic acid compound, and is sufficiently pure to form a dry, solid herbicidal salt composition after interaction with a suitable neutralizing base, such as ammonia, an alkylamine, a dialkylamine, a trialkylamine, a hydroxyalkylamine, a dihydroxyalkylamine, an alkaline salt of an alkali metal or a combination thereof. The dry herbicidal salt composition includes at least about 90% by weight of the water-soluble herbicidal salt, and dissolves rapidly and essentially completely in water to form an aqueous herbicidal solution including up to about 75% by weight of the water-soluble herbicidal salt.

Substituted pyridinesulfonamide compounds or their salts, process for preparing the same, and herbicides containing the same

A substituted pyridinesulfonamide compound or its salt represented by the following general formula (I): wherein R1 is an unsubstituted or substituted alkyl group; R2 is an unsubstituted or substituted alkyl group, or an unsubstituted or substituted alkoxy group; and X and Y are each independently a member selected from the group consisting of alkyl groups and alkoxy groups, is disclosed. This compound is useful as the effective ingredient of a herbicide showing a wide weed-control spectrum even if used in a small amount.

Controlled release of bioactive materials using alginate gel beads

Alginate gel beads containing bioactive materials dispersed therein are the product and the process of this invention. These beads can be made to either float or sink in aqueous environments, and are capable of providing the controlled release of their bioactive materials when applied to terrestrial or aqueous environments.

Controlled release of bioactive materials using alginate gel beads

Alginate gel beads containing bioactive materials dispersed therein are the product and the process of this invention. These beads can be made to either float or sink in aqueous environments, and are capable of providing the controlled release of their bioactive materials when applied to terrestrial or aqueous environments.