145-73-3 Hazards Identification
Pictogram(s):
Signal:
Danger
GHS Hazard Statements:
H301: Toxic if swallowed [Danger Acute toxicity, oral]
H312: Harmful in contact with skin [Warning Acute toxicity, dermal]
H315: Causes skin irritation [Warning Skin corrosion/irritation]
H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement Codes:
P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
Hazard Classes and Categories:
Acute Tox. 3 *
Acute Tox. 4 *
STOT SE 3
Skin Irrit. 2
Eye Irrit. 2
Acute Tox. 2 (92.68%)
Acute Tox. 4 (100%)
Skin Irrit. 2 (100%)
Eye Irrit. 2 (100%)
STOT SE 3 (100%)
Aquatic Acute 1 (92.68%)
Eye irritation - category 2
Specific target organ toxicity (single exposure) - category 3
Skin irritation - category 2
Acute toxicity (ingestion) - category 3
Acute toxicity (dermal) - category 4
Acute toxicity (Oral) - Category 3
Acute toxicity (Inhalation: Dusts and mists) - Category 4
Skin corrosion/irritation - Category 2
Serious eye damage/eye irritation - Category 2A
Specific target organ toxicity - Single exposure - Category 1 (nervous system)
Specific target organ toxicity - Repeated exposure - Category 2 (liver, stomach, testis)
Hazards Summary:
Non-corrosive; [CAMEO] In human poisoning cases, ingestion of 7-8 grams of disodium endothall caused vomiting and gastrointestinal bleeding. The oral LD50 (rats) for technical grade endothall is 38 mg/kg. Experimental animals suffer liver and kidney damage in high-dose feeding studies. [EXTOXNET] A skin sensitizer; [Reference #2]
145-73-3 Usage
Uses
Used in Agricultural Industry:
ENDOTHAL is used as a defoliant and herbicide for the control of broad-leaved weeds and annual grass in vegetable crops. It is also employed as a cotton defoliant and as a selective contact herbicide on both terrestrial and aquatic weeds. The potassium and amine salts of ENDOTHAL are used as aquatic herbicides to control a variety of plants, including plankton, pondweed, niad, coontail, milfoil, elodea, and algaes in water bodies and rice fields. Additionally, ENDOTHAL is used to control annual grass and broadleaf weeds in sugar beets, spinach, and turf. It also reduces sucker branch growth in hops and acts as a desiccant to aid the harvest of alfalfa, potatoes, clover, and cotton. It is approved for use in the U.S. and other countries, but not in EU countries.
Used in Pharmaceutical Industry:
ENDOTHAL is used as an inhibitor of PP2A phosphatase activity and is also employed as a cell adhesion inhibitor.
Air & Water Reactions
Stable up to 90°C, above which ENDOTHAL undergoes slow hydrolysis.
Reactivity Profile
A phthalic acid derivative.
Hazard
Strong irritant to eyes and skin.
Trade name
ACCELERATE?; AQUATHOL?;
DES-I-CATE?; HYDOUT?; HYDROTHAL-47?;
HYDROTHOL?; NIAGARATHOL?; RIPENTHOL?;
TRI-ENDOTHAL?
Safety Profile
Poison by ingestion.
Very irritating to skin, eyes, and mucous
membranes. Causes dlarrhea. When heatedto decomposition it emits acrid smoke and
fumes
Potential Exposure
Endothall is dicarboxylic acid defoliant and herbicide used on both terrestrial and aquatic
weeds.
Environmental Fate
Biological. Incubation of 14C-ring labeled endothall (10 mg/mL) by Arthrobacter sp.,
which was isolated from pond water and a hydrosol, in aerobic sediment-water suspensions
revealed that after 30 days, 40% evolved as 14CO2. Glutamic acid was the major transformation
product. Minor products were alanine, citric and aspartic acids and unidentified
products, some of which were tentatively identified as phosphate esters (Sikka and Saxena,
1973). In pond water treated with endothall (2 and 4 ppm), detectable levels were found
after 7 days (Sikka and Rice, 1973). Biodegradation was rapid in an Ontario soil sample.
After 1 week, 70% of endothall added was converted to carbon dioxide (Simsiman et al.,
1976).
Chemical/Physical. Reacts with bases forming water-soluble salts. Above 90°C, endothall
is slowly converted to the anhydride (Windholz et al., 1983; Hartley and Kidd, 1987)
and water (Humburg et al., 1989). Endothall is stable to light (Hartley and Kidd, 1987).
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name
Required. UN2588 Pesticides, solid, toxic, Hazard Class: 6.1;
Labels: 6.1-Poisonous materials, Technical Name Required.
Incompatibilities
Compounds of the carboxyl group react
with all bases, both inorganic and organic (i.e., amines)
releasing substantial heat, water and a salt that may be
harmful. Incompatible with arsenic compounds (releases
hydrogen cyanide gas), diazo compounds, dithiocarbamates,
isocyanates, mercaptans, nitrides, and sulfides (releasing
heat, toxic, and possibly flammable gases), thiosulfates and
dithionites (releasing hydrogen sulfate and oxides of sulfur)
Waste Disposal
Small quantities may be disposed of by burial in soil which is rich in organic matter.
Large quantities are best disposed of by incineration.
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste
containing this contaminant (5100 kg/mo) must conform
with EPA regulations governing storage, transportation,
treatment, and waste disposal. In accordance with
40CFR165, follow recommendations for the disposal of
pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting
your local or federal environmental control agency, or by
contacting your regional EPA office
Check Digit Verification of cas no
The CAS Registry Mumber 145-73-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 5 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 145-73:
(5*1)+(4*4)+(3*5)+(2*7)+(1*3)=53
53 % 10 = 3
So 145-73-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H10O5/c9-7(10)5-3-1-2-4(13-3)6(5)8(11)12/h3-6H,1-2H2,(H,9,10)(H,11,12)
145-73-3Relevant academic research and scientific papers
Xu, Gang,Lin, Jing,Li, Wanchun,Zhao, Jian,Gou, Shaohua
, p. 188 - 194 (2017)
Nine platinum(II) complexes with N-monoalkyl 1R,2R-DACH derivatives as carrier ligands and demethylcantharidate as a leaving group were synthesized and spectrally characterized. All the complexes showed considerable cytotoxicity against tested human cancer cell lines: A549, HCT116 HepG-2 and MCF7 cell lines. Especially, complex 2 exhibited potent cytotoxicity against A549 (1.01?μM) and HCT116 (0.83?μM) cell lines, and showed no cross-resistance to cisplatin against SGC7901/CDDP cell line (RF?=?1.44). In addition, the typical compounds were further studied by flow cytometric analysis and western blot method. The results indicated that they induced apoptosis by a mitochondrial-dependent pathway, which were similar to cisplatin.
Homogeneous, stable and flowable aqueous mixtures and dispersions of water-insoluble substances formulated therefrom exhibiting optical birefringence
-
, (2008/06/13)
Stable and flowable aqueous dispersions of at least one water-insoluble material are formulated by dispersing such water-insoluble material, e.g., solid particulates of a plant protection compound, into a homogeneous, stable and flowable aqueous composition that includes (1) at least one water-soluble derivative of a plant protection active agent bearing at least one ionizable functional group and at least one hydrophilic functional group, (2) at least one nonionic surface-active agent and/or at least one aliphatic, cycloaliphatic or arylaliphatic alcohol having from 4 to 15 carbon atoms, and (3) water, this composition exhibiting optical birefringence and a yield point of at least 0.1 pascal.
Substituted pyridinesulfonamide compound or its salt, process for preparing the same, and herbicide containing the same
-
, (2008/06/13)
A substituted pyridinesulfonamide compound or its salt represented by the following general formula (I): STR1 wherein A is CH or N; when A is CH, R1 and R2 may be either each independently a member selected from the group consisting of unsubstituted or substituted alkyl groups, unsubstituted or substituted alkenyl groups, unsubstituted or substituted cycloalkyl groups, and unsubstituted or substituted phenyl groups; when A is N, R1 is an unsubstituted or substituted alkyl group, R2 is an unsubstituted or substituted alkyl group, or an unsubstituted or substituted alkoxy group; and X and Y are each independently a member selected from the group consisting of alkyl groups and alkoxy groups, is disclosed. This compound is useful as the effective ingredient of a herbicide showing a wide weed-control spectrum even if used in a small amount.
Method of manufacturing a dry water-soluble herbicidal salt composition
-
, (2008/06/13)
A method of manufacturing a solid, water-soluble herbicidal composition comprising a water-soluble salt of a herbicidal compound is disclosed. The herbicidal compound is a water-insoluble compound that includes a carboxylic acid functionality, such as a phenoxy-substituted carboxylic acid compound or a substituted benzoic acid compound, and is sufficiently pure to form a dry, solid herbicidal salt composition after interaction with a suitable neutralizing base, such as ammonia, an alkylamine, a dialkylamine, a trialkylamine, a hydroxyalkylamine, a dihydroxyalkylamine, an alkaline salt of an alkali metal or a combination thereof. The dry herbicidal salt composition includes at least about 90% by weight of the water-soluble herbicidal salt, and dissolves rapidly and essentially completely in water to form an aqueous herbicidal solution including up to about 75% by weight of the water-soluble herbicidal salt.
Substituted pyridinesulfonamide compounds or their salts, process for preparing the same, and herbicides containing the same
-
, (2008/06/13)
A substituted pyridinesulfonamide compound or its salt represented by the following general formula (I): wherein R1 is an unsubstituted or substituted alkyl group; R2 is an unsubstituted or substituted alkyl group, or an unsubstituted or substituted alkoxy group; and X and Y are each independently a member selected from the group consisting of alkyl groups and alkoxy groups, is disclosed. This compound is useful as the effective ingredient of a herbicide showing a wide weed-control spectrum even if used in a small amount.
Controlled release of bioactive materials using alginate gel beads
-
, (2008/06/13)
Alginate gel beads containing bioactive materials dispersed therein are the product and the process of this invention. These beads can be made to either float or sink in aqueous environments, and are capable of providing the controlled release of their bioactive materials when applied to terrestrial or aqueous environments.
Controlled release of bioactive materials using alginate gel beads
-
, (2008/06/13)
Alginate gel beads containing bioactive materials dispersed therein are the product and the process of this invention. These beads can be made to either float or sink in aqueous environments, and are capable of providing the controlled release of their bioactive materials when applied to terrestrial or aqueous environments.
