1450-90-4

Basic information

• Product Name: 4,6-bis(methylsulfanyl)pyrimidine
• Synonyms: 4,6-Bis(methylthio)pyrimidine
• CAS NO: 1450-90-4
• Molecular Formula: C₆H₈N₂S₂
• Molecular Weight: 172.2711
• Mol File: 1450-90-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 294.5°C at 760 mmHg
• Flash Point: 131.9°C
• Density: 1.26g/cm³
• Vapor Pressure: 0.00284mmHg at 25°C
• Refractive Index: 1.615
• CAS DataBase Reference: 4,6-bis(methylsulfanyl)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-bis(methylsulfanyl)pyrimidine(1450-90-4)
• EPA Substance Registry System: 4,6-bis(methylsulfanyl)pyrimidine(1450-90-4)

Safety Data

• Hazardous Substances Data: 1450-90-4(Hazardous Substances Data)

Usage

General Description

4,6-bis(methylsulfanyl)pyrimidine is a chemical compound with the formula C6H8N2S2. It is a pyrimidine derivative consisting of a six-membered ring containing two nitrogen atoms at positions 1 and 3, and two sulfur atoms at positions 4 and 6. 4,6-bis(methylsulfanyl)pyrimidine is commonly used in the pharmaceutical industry as a building block for the synthesis of various chemicals, including pharmaceutical drugs. It has been found to exhibit potential biological activities, such as antifungal and antibacterial properties. Additionally, it has also been studied for its potential use in organic electronics and as a precursor for the preparation of heterocyclic compounds. Overall, 4,6-bis(methylsulfanyl)pyrimidine is a versatile compound that has applications in various fields, including medicine, chemistry, and materials science.

Upstream product

• 1193-21-1 4,6-dichloropyrimidine 
• 5188-07-8 sodium thiomethoxide 
• 353-43-5 boron dimethyl-trifluoro sulphide 
• 616-38-6 carbonic acid dimethyl ester 

Relevant articles and documents

BF3·SMe2 for Thiomethylation, Nitro Reduction and Tandem Reduction/SMe Insertion of Nitrogen Heterocycles

Herein, a general, solvent-free and straightforward thiomethylation of electron deficient heterocycles using BF3·SMe2 as a dual thiomethyl source and Lewis acidic activator is presented. A range of heterocycles including pyrimidine, pyrazine, pyridazine, thiazole and purine derivatives were successfully substituted using this method. An unexpected reductive property of BF3·SMe2 towards nitropyridines was also discovered including an intriguing tandem reduction/SMe insertion process in certain substrates. Notable features of the present work include its convenience and use of a non-malodorous reagent while the discovery of novel chemical transformations using BF3·SMe2 provides fundamental new insights into the reactivity of this commonly employed reagent.

Methyl aryl thioether compound, and synthetic method and applications thereof

The invention discloses a methyl aryl thioether compound represented by formula 2, and a synthetic method and applications thereof. According to the synthetic method, in a reaction solvent, an aryl halide or an aromatic halide, dimethyl carbonate, and potassium thioacetate are taken as reaction raw materials, reaction is carried out in the presence of metal palladium catalyst under the action of a ligand and an alkali so as to obtain the methyl aryl thioether compound. The reaction conditions of the synthetic method are mild; the raw materials are cheap and easily available; reaction operation is simple; yield is relatively high. The methyl aryl thioether compound can be used for providing skeleton structures for the synthesis of a plurality of natural products and medicines, and can be widely applied in industrialized large-scale production.

[4,5']BIPYRIMIDINYL-6,4'-DIAMINE DERIVATIVES AS PROTEIN KINASE INHBITORS

The invention provides a novel class of compounds of the Formula (I): in which the symbols have the meanings given in the description and claims, to pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prev