145012-65-3Relevant academic research and scientific papers
Employing BINOL-Phosphoroselenoyl Chloride for Selective Inositol Phosphorylation and Synthesis of Glycosyl Inositol Phospholipid from Entamoeba histolytica
Aiba, Toshihiko,Suehara, Sae,Choy, Siew-Ling,Maekawa, Yuuki,Lotter, Hannelore,Murai, Toshiaki,Inuki, Shinsuke,Fukase, Koichi,Fujimoto, Yukari
, p. 8304 - 8308 (2017)
The chemical synthesis of glycosyl inositol phospholipids from Entamoeba histolytica is reported. The key feature of this synthesis is a regioselective phosphorylation reaction that occurs through desymmetrization of a myo-inositol derivative with phosphoroselenoyl chloride. A new protecting-group strategy was developed that utilizes allyl and alloc groups to synthesize complex glycolipids bearing unsaturated lipids. These developments provided an efficient synthetic route for various complex inositol phospholipids and their analogues. Furthermore, the binding affinity of the synthetic inositol phospholipids with mouse CD1d molecules has been evaluated, as well as the immunostimulatory activity.
The first enzymatic degradation products of the antibiotic moenomycin A.
Metten, Karl-Heinz,Hobert, Kurt,Marzian, Susanne,Hackler, Ulrich E.,Heinz, Uwe,Welzel, Peter,Aretz, Werner,Boettger, Dirk,Hedtmann, Udo,Seibert, Gerhard,Markus, Astrid,Limbert, Michael,Van Heijenoort, Yveline,Van Heijenoort, Jean
, p. 8401 - 8418 (2007/10/02)
Moenomycin A was degraded by enzymatic cleavage of the bond between the moenuronic acid moiety and the phosphate group. The phosphoric acid monoester 4a could be dephosphorylated further to yield 3a. Compound 3a was used to confirm the previous configurat
