145012-94-8Relevant academic research and scientific papers
ANTI-INFLAMMATORY DRUG AND USES THEREOF
-
Paragraph 0202; 0203, (2018/05/24)
An anti-inflammatory drug containing a G0/G1 switch 2 (G0S2) inhibitor as an active ingredient is useful as a novel anti-inflammatory drug.
N, N-di-boc-substituted thiourea as a novel and mild thioacylating agent applicable for the synthesis of thiocarbonyl compounds
Yin, Biao-Lin,Liu, Zhao-Gui,Zhang, Jian-Cun,Li, Zheng-Rong
experimental part, p. 991 - 999 (2010/06/11)
Stable and readily available N,N-di-Boc-substituted thiourea, when activated with trifluoroacetic acid anhydride, was used as a novel thioacylating agent. Through the thioacylation of nucleophiles, such as amines, alcohols, thiols, sodium benzene-thiolate
DIHYDROPYRIMIDINONES FOR USE AS BACE2 INHIBITORS
-
Page/Page column 37, (2010/11/18)
This invention relates to dihydropyrimidinones of the formula (I), wherein X and R1 to R7 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are BACE2 inhibitors
An efficient method for the synthesis of disubstituted thioureas via the reaction of N,N′-di-Boc-substituted thiourea with alkyl and aryl amines under mild conditions
Yin, Biaolin,Liu, Zhaogui,Yi, Mingjun,Zhang, Jiancun
, p. 3687 - 3690 (2008/09/20)
An efficient method for the synthesis of disubstituted thioureas via the reaction of N,N′-di-Boc-substituted thiourea 5 with alkyl and aryl amines under mild conditions has been developed. In the presence of NaH as a base, trifluoroacetic anhydride (TFAA)
A Mild and Efficient Method for the Preparation of Guanidines
Poss, Michael A.,Iwanowicz, Edwin,Reid, Joyce A.,Lin, James,Gu, Zhengxiang
, p. 5933 - 5936 (2007/10/02)
A mild and efficient method for the preparation of guanidines by reaction of an acylated thiourea with an amine followed by removal of the acyl groups(s) from the intermediate acylguanidine is reported.Key Words: acylguanidine, acylthiourea, guanidine, water soluble carbodiimide
