145017-83-0

Basic information

• Product Name: OMEGA-AGATOXIN TK
• Synonyms: OMEGA-AGA-IVB;OMEGA-AGA-TK;OMEGA-AGATOXIN TK;OMEGA-AGATOXIN TK, AGELENOPSIS APERTA;GLU-ASP-ASN-CYS-ILE-ALA-GLU-ASP-TYR-GLY-LYS-CYS-THR-TRP-GLY-GLY-THR-LYS-CYS-CYS-ARG-GLY-ARG-PRO-CYS-ARG-CYS-SER-MET-ILE-GLY-THR-ASN-CYS-GLU-CYS-THR-PRO-ARG-LEU-ILE-MET-GLU-GLY-LEU-D-SER-PHE-ALA;ω-aga-tk;ω-agatoxin tk;OMEGA-AGATOXIN TK (P-TYPE BLOCKER)
• CAS NO: 145017-83-0
• Molecular Formula: C215H337N65O70S10
• Molecular Weight: 5273.02
• Product Categories: Ion Channels;proteins
• Mol File: 145017-83-0.mol
• Article Data: 0

Chemical Properties

• Appearance: /powder
• Storage Temp.: −20°C
• Solubility: H2O: Aqueous stock solution is stable for 1 month at 2-8?#x00b0
• CAS DataBase Reference: OMEGA-AGATOXIN TK(CAS DataBase Reference)
• NIST Chemistry Reference: OMEGA-AGATOXIN TK(145017-83-0)
• EPA Substance Registry System: OMEGA-AGATOXIN TK(145017-83-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 145017-83-0(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 145017-83-0 differently. You can refer to the following data:
1. ω-Agatoxin IVA has been used in the manipulation of calcium influx. It has also been used in the study to characterize the spontaneous and evoked activity from murine ventral horn cultures on microelectrode arrays.
2. omega-Agatoxin TK is a selective blocker of the P-type Ca2+?channel.

General Description

CACNA1A (calcium voltage-gated channel subunit alpha1 A)?gene codes for the α1 subunit of neuronal CaV2.1 (P/Q-type) voltage-gated calcium channels. It is expressed throughout the central nervous system (CNS). CACNA1A gene is located on human chromosome 19p13.

Biochem/physiol Actions

Toxin found in the venom of the funnel web spider, Agelenopsis aptera. Potent, selective blocker of mammalian P-type voltage-dependent calcium channels.