14502-46-6Relevant academic research and scientific papers
IRAK DEGRADERS AND USES THEREOF
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Paragraph 00794; 001103; 001110-001111, (2021/01/23)
The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.
Synergistic Gold and Copper Dual Catalysis for Intramolecular Glaser–Hay Coupling: Rapid Total Synthesis of Ivorenolide B
Rangaraju, Sudheer K.,Gonela, Uma Maheshwar,Kavita, Aala,Yadav, Jhillu S.,Mohapatra, Debendra K.
, p. 4376 - 4380 (2018/09/11)
A synergistic dual catalysis approach involving gold and copper catalysts for the synthesis of macrolactones bearing 1,3-butadiynes through an intramolecular Glaser–Hay coupling reaction in good yield is described. This dual catalytic system exhibited good selectivity, reactivity and functional group tolerance. This unique process offers a paradigm shift: the potential as well as the versatility of this novel method is not only exemplified for the synthesis of macrolactones of different ring size but also for the rapid total synthesis of ivorenolide B, a new class of macrolides endowed with conjugated 1,3-diyne motif, having impressive immunosuppressive activities.
Lipid analysis
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Page/Page column, (2014/01/17)
The present invention relates to a method for the detection of a lipid comprising reacting an alkyne-modified lipid derivative and an azido-modified coumarin compound, purifying the resulting compound using chromatography and detecting the reaction product. In a further aspect the present invention provides new alkyne lipid derivatives, new methods of alkyne lipid synthesis, new uses of such compounds and new methods employing these compounds.
Reversible color changes in lamella hybrids of poly(diacetylenecarboxylates) incorporated in layered double hydroxide nanosheets
Itoh, Toshio,Shlchi, Tetsuya,Yui, Tatsuto,Takahashi, Hiroki,Inui, Yoshihisa,Takagi, Katsuhiko
, p. 3199 - 3206 (2008/03/14)
The present study is an investigation of a reversible thermal color change induced in lamella hybrids of poly(diacetylenecarboxylates) incorporated in layered double hydroxide (LDH) nanosheets. These poly-[m,n]/ LDH hybrids prepared by the photo- or ?3-ray-induced polymerization of diacetylenecarboxylates, i.e., CH3-(CH2) m-1Ca??C-Ca??C(CH2)n-1CO 2- (mono-[m,n]), and intercalated in LDH lamella sheets, were observed to develop colors ranging from yellow to blue. The change in color was found to depend greatly on the alkyl carbon numbers of the mono-[m,n] (m,n = 10,11; 5,11; 10,5; 16,1) values. Moreover, the conformational alignment of the mono-[m,n] within the LDH was observed to be a crucial factor in color development, which was greatly affected by the intercalation degrees and extent of poly(ene-yne) linkage elongation of the polymers. For the poly-[m,n]/LDH hybrids investigated, a reversible color change was found to occur repeatedly and remarkably for the poly-[10,11]/LDH hybrid. This color change occurred at temperatures between ca. 20 and 80?°C back and forth from purple red to bright orange, in stark contrast to the irreversible color change for poly-[10,11] without LDH. Moreover, DSC and Raman spectroscopic studies of the LDH hybrids showed that the thermochromic temperature corresponded to the phase transition temperature of 80?°C. XRD analysis also indicated that the poly-[m,n]/LDH hybrid could retain its lamella structure during such thermochromic color changes, enabling conformational recovery in the polymer chains by a cooling down of the hybrids to temperatures lower than the transition temperature, while the nonhybrid poly-[10,11] powders exhibited an irreversible color change at 60?°C, above which the polymer powder turned amorphous. ? 2005 American Chemical Society.
A GENERAL METHOD FOR THE SYNTHESIS OF DIACETYLENIC ACIDS
Singh, Alok,Schnur, Joel M.
, p. 847 - 852 (2007/10/02)
A simple and convenient method for the synthesis of twelve novel alkadiynoic acids, HOOC(CH2)mCC-C-CC(CH2)n-CH3, is reported.
THIA-ACYLIMINIUM CYCLISATIONS. SYNTHESIS OF FIVE-MEMBERED RINGS AND MACROCYCLES
Hamersma, J. A. M.,Nossin, P. M. M.,Speckamp, W. N.
, p. 1999 - 2006 (2007/10/02)
Cyclisations of carbinollactams 1b-3b afford macrocycles 4-6 in good yield by the intermediacy of N-acyliminium species.A similar process applied to lactams 21b-25b affords the pyrrolizidine type compounds 26-35 through consecutive azonium-Cope rearrangem
