145029-82-9

Basic information

• Product Name: 4-(2-Fluoro-phenyl)-thiazol- 2-ylamine
• Synonyms: 4-(2-Fluorophenyl)thiazol-2-amine
• CAS NO: 145029-82-9
• Molecular Formula: C9H7FN2S
• Molecular Weight: 194.23
• Mol File: 145029-82-9.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(2-Fluoro-phenyl)-thiazol- 2-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Fluoro-phenyl)-thiazol- 2-ylamine(145029-82-9)
• EPA Substance Registry System: 4-(2-Fluoro-phenyl)-thiazol- 2-ylamine(145029-82-9)

Safety Data

• Hazardous Substances Data: 145029-82-9(Hazardous Substances Data)

Usage

General Description

4-(2-Fluoro-phenyl)-thiazol-2-ylamine is a chemical compound with the molecular formula C10H8FN3S. It is a thiazole derivative that contains a fluorophenyl group and an amino group attached to a thiazole ring. 4-(2-Fluoro-phenyl)-thiazol- 2-ylamine has potential applications in pharmaceutical research and drug development due to its biological activity and ability to interact with biological targets. Thiazole compounds, in general, have been found to exhibit antibacterial, antifungal, and antiviral properties, making them promising candidates for the development of novel therapeutic agents. Additionally, the fluorophenyl group can enhance the compound's biological activity and pharmacokinetic properties. Further research is needed to fully understand the potential uses and effects of 4-(2-Fluoro-phenyl)-thiazol-2-ylamine.

Upstream product

• 445-27-2 2'-Fluoroacetophenone 
• 655-15-2 2-bromo-2'-fluoroacetophenone 
• 17356-08-0 thiourea 

Downstream Products

• 1449016-04-9 N-[4-(o-fluorophenyl)-1,3-thiazol-2-yl]-2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamide 

Relevant articles and documents

A one-pot synthesis of 2-aminothiazoles via the coupling of ketones and thiourea using I2/dimethyl sulfoxide as a catalytic oxidative system

A series of 2-aminothiazoles is prepared in moderate-to-good yields by the direct coupling of ketones and thiourea using I2/dimethyl sulfoxide as a catalytic oxidative system. This method avoids the preparation of lachrymatory and toxic α-haloketones and the use of an acid-binding agent, thus providing a more convenient approach to 2-aminothiazoles compared to the Hantzsch reaction.

Method for preparing 2-aminothiazole compound

The invention discloses a method for preparing a 2-aminothiazole compound. The method comprises the following steps: in an organic solvent, carrying out a condensation reaction on thiourea representedby a formula (II) and a ketone compound represented by a formula (III) at 50-120 DEG C for 6-24 h under the catalysis of elemental iodine, and after the reaction is finished, carrying out post-treatment on the reaction solution to obtain the 2-aminothiazole compound represented by a formula (I). According to the invention, the method has characteristics of cheap and easily available reaction rawmaterials, mild reaction conditions, simpleness, no requirement of transition metal catalysts and a stoichiometric halogenating reagents and cost reducing, and can be used for synthesizing a series of2-aminothiazole derivatives, and the prepared products can be used as important intermediates for synthesizing thiazole structure-containing drugs or bioactive compounds.

Substituted thiazole derivative and application thereof

The invention provides a compound represented by a general formula (I), or a stereoisomer, pharmaceutically acceptable salt, solvate, hydrate, chemically protective form or prodrug thereof. The compound has an effect of inhibiting adenosine receptor 2a (A2a), and can be used as an antagonist of the adenosine receptor 2a (A2A) for treating tumors.