14503-49-2

Upstream product

• 171365-17-6 2-(1-Benzyl-1H-indol-3-yl)ethyl acetate 
• 526-55-6 2-(3-indole)-ethanol 
• 14602-03-0 1-benzyl-3-(2-hydroxyethyl)indole 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 171365-19-8 1-Benzyl-3-(2-chloroethyl)-1H-indole 
• 171484-70-1 (4R,6S)-6-<2-(1-Benzyl-1H-indol-3-yl)ethyl>-4-<(tert-butyldimethylsilyl)oxy>tetrahydro-2H-pyran-2-one 
• 171365-24-5 (4R,6R)-6-<2-(1-Benzyl-1H-indol-3-yl)ethyl>-4-<(tert-butyldimethylsilyl)oxy>tetrahydro-2H-pyran-2-one 
• 171365-23-4 (4R,6S,1'S)-6-<2-(1-Benzyl-1H-indol-3-yl)-1-iodoethyl>-4-<(tert-butyldimethylsilyl)oxy>tetrahydro-2H-pyran-2-one 
• 171484-69-8 (4R,6R,1'R)-6-<2-(1-Benzyl-1H-indol-3-yl)-1-iodoethyl>-4-<(tert-butyldimethylsilyl)oxy>tetrahydro-2H-pyran-2-one 

Relevant academic research and scientific papers

Synthesis of Novel HMG-CoA Reductase Inhibitors, II. Heterocyclic Analogs of Mevinolin

The indole (1) and chroman analogs (2) of mevinolin and their 6S diastereomers 15c and 25d were synthesized in several steps starting with methyl (R)-3--4-formylbutyrate (12) and 2-(indol-3-yl)ethanol (3) or 6-methoxychroman-4-one (16), respectively.Compounds 1 and 2 inhibited moderately the HMG-CoA reductase.The diastereomers 15c and 25d were shown to be inactive. - Keywords: HMG-CoA reductase inhibitors / 3-Indolylheptanoates and -acetates / 4-Chromanylheptanoates and -acetates