145042-91-7

Basic information

• Product Name: (3-acetyl-4-hydroxyphenyl)acetic acid methyl ester
• Synonyms: (3-acetyl-4-hydroxyphenyl)acetic acid methyl ester
• CAS NO: 145042-91-7
• Molecular Weight: 208.214
• Mol File: 145042-91-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (3-acetyl-4-hydroxyphenyl)acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3-acetyl-4-hydroxyphenyl)acetic acid methyl ester(145042-91-7)
• EPA Substance Registry System: (3-acetyl-4-hydroxyphenyl)acetic acid methyl ester(145042-91-7)

Safety Data

• Hazardous Substances Data: 145042-91-7(Hazardous Substances Data)

Upstream product

• 35400-15-8 4-acetoxyphenylacetic acid methyl ester 

Downstream Products

• 1224712-22-4 methyl 2-(3-acetyl-5-bromo-4-hydroxyphenyl)acetate 
• 185802-77-1 3-acetyl-4-(3-bromopropoxy)phenylacetic acid 
• 203071-83-4 [4-(3-Bromo-propoxy)-3-ethyl-phenyl]-acetic acid methyl ester 
• 185802-75-9 4-(3-bromopropoxy)-3-ethylphenylacetic acid 
• 750572-56-6 [3-(3-adamantan-1-yl-3-oxo-propionyl)-4-hydroxy-phenyl]-acetic acid methyl ester 
• 203071-82-3 [3-Acetyl-4-(3-bromo-propoxy)-phenyl]-acetic acid methyl ester 
• 750572-53-3 adamantane-1-carboxylic acid 2-acetyl-4-methoxycarbonylmethylphenyl ester 

Relevant articles and documents

Synthesis and biological evaluation of phenylacetyl derivatives having low central nervous system permeability as potent and selective M2 muscarinic receptor antagonists

A series of phenylacetyl derivatives containing the 5,10-dihydro-11H- dibenzo[b,e][1,4]diazepin-11-one or 5,11-dihydro-6H-pyrido[2,3- b][1,4]benzodiazepin-6-one skeleton was prepared and evaluated for their binding affinities to muscarinic receptors in vitro and for antagonism of bradycardia, salivation and tremor in vivo. Among them, compounds 56 and 66 had high affinity for M2 muscarinic receptors in the heart (pK(i) = 8.7 and 8.9, respectively) with low affinity for M3 muscarinic receptors in the submandibular gland. A structure-activity relationship (SAR) study suggested that the high M2 selectivity over the M3 muscarinic receptors of 56 may be attributed to the direction of the carboxamide carbonyl group. In in vivo studies, 56 and 66 antagonized oxotremorine-induced bradycardia in rats on both intravenous and oral administration, and their heart rate increasing effect in dogs with nocturnal bradycardia was about 3-fold greater than that of AF-DX 116. Furthermore, they had almost no influence on oxotremorine- induced tremor in mice, presenting no evidence of central transfer.

BENZENE COMPOUND HAVING 2 OR MORE SUBSTITUENTS

A superior LXR modulator is provided. A compound represented by the general formula (I): [wherein R1: -COR9 (wherein R9: alkyl, optionally substituted alkoxy or optionally substituted amino); R2: H, OH, alkoxy, optionally substituted amino, etc.; R3: H, optionally substituted alkyl, cycloalkyl, optionally substituted alkoxy, optionally substituted amino, halogeno, etc.; R4 and R5: H, optionally substituted alkyl, halogeno, etc.; R6 and R7: H, alkyl; R8: -X2R10 [wherein R10: -COR11 (wherein R11 : OH, optionally substituted alkoxy, optionally substituted amino, etc.), -SO2R12 (wherein R12: optionally substituted alkyl, optionally substituted amino, etc.), tetrazol-5-yl, etc.; X2: single bond, optionally substituted alkylene, etc.]; X1: -NH-, -O-, -S-, etc.; Y1: optionally substituted phenyl, optionally substituted 5- to 6-membered aromatic heterocyclyl; Y2: optionally substituted aryl, optionally substituted heterocyclyl, etc.] and the like is provided.