14505-32-9

Basic information

• Product Name: 3-methyl-2-(phenylamino)quinazolin-4(3H)-one
• CAS NO: 14505-32-9
• Molecular Formula: C₁₅H₁₃N₃O
• Molecular Weight: 251.2832
• Mol File: 14505-32-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 412.8°C at 760 mmHg
• Flash Point: 203.4°C
• Density: 1.22g/cm³
• Vapor Pressure: 5.05E-07mmHg at 25°C
• Refractive Index: 1.649
• CAS DataBase Reference: 3-methyl-2-(phenylamino)quinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-2-(phenylamino)quinazolin-4(3H)-one(14505-32-9)
• EPA Substance Registry System: 3-methyl-2-(phenylamino)quinazolin-4(3H)-one(14505-32-9)

Safety Data

• Hazardous Substances Data: 14505-32-9(Hazardous Substances Data)

Usage

General Description

3-methyl-2-(phenylamino)quinazolin-4(3H)-one is a chemical compound with the molecular formula C16H13N3O. It is a quinazolinone derivative with a phenylamino group attached to the 2-position of the quinazoline ring. 3-methyl-2-(phenylamino)quinazolin-4(3H)-one is a white solid with a molecular weight of 263.29 g/mol. It has potential applications in the pharmaceutical industry due to its structural properties, which make it a valuable intermediate for the synthesis of various bioactive compounds. The compound may also have biological activities that could potentially be beneficial for the treatment of certain diseases and conditions.

Upstream product

• 32709-38-9 N-Methyl-o-azido-benzamid 
• 125728-76-9 1-{4-[(Z)-Methylimino]-4H-benzo[d][1,3]oxazin-2-yl}-1,3-diphenyl-urea 
• 118988-18-4 N-methyl o-(triphenylphosphoranylidene)amino benzamide 
• 103-71-9 phenyl isocyanate 

Relevant articles and documents

NEW METHODOLOGY FOR THE PREPARATIONOF QUINAZOLINE DERIVATIVES VIA TANDEM AZA-WITTIG/HETEROCUMULENE-MEDIATED ANNULATION. SYNTHESIS OF 4(3H)QUINAZOLINONES, BENZIMIDAZOQUINAZOLINES, QUINAZOLINOQUINAZOLINES AND BENZOTHIAZOLOQUINAZOLINES.

The aza-Wittig reaction of iminophosphoranes derived from N-substituted o-azidobenzamides, 2-(o-azidophenyl)-benzimidazole, -benzothiazole or -3,1-benzoxazin-4-one with heterocumulenes leads to functionalized quinazolines.Iminophosphoranes 9, derived from N-substituted o-azidobenzamides, react under mild conditions with isocyanates to form 4H-3,1-benzoxazine-4-imines 11 which are converted into 2-substituted-4(3H)-quinazolinones 12.Iminophosphoranes 9 also react with carbon disulfide and carbon dioxide to give the quinazolinones 13 and 14 respectively.Iminophosphorane 26, derived from 2-(o-azidophenyl)benzimidazole, reacts with isocyanates, carbon disulfide and carbon dioxide to form 6-substituted benzimidazoquinazolines 27, 28, and 29 respectively.In benzene at room temperature, iminophosphorane 31, reacts with isocyanates yielding quinazolinoquinazolines 34.Compounds 34 can also be prepared from iminophosphorane 36 and isocyanates.Iminophosphorane 40 derived from 2-(o-azidophenyl)benzothiazole reacts with aliphatic and aromatic isocyanates or isothiocyanates to give 7H-benzothiazoloquinazoline-7-imines 42.Iminophosphorane 40 also reacts with carbon dioxide or carbon disulfide to afford the corresponding isocyanate 43 or isothiocyanate 44, The molecular structures of 11d and 42a have been determined by X-ray diffraction methods.